유방암에서 c-erbB-2 단백 과벌현에 관한 연구 -임상 예후 인자, 세포증식능, 수용체 양성 여부, 조직학적 소견과의 관계에 대하여-
c-erbB-2 Oncoprotein Overexpression in Breast Carcinoma -Correlation of clinical prognostic factor, proliferative activity, hormonal receptor status and hisologic findings-
대한암학회지 1995년 27권 5호 p.721 ~ 729
소속 상세정보
안혜경
김윤정/심정원/박영의/정경석
KMID : 0360319950270050721
Abstract
Receptor status, proliferative activity, loss of differentiation, age, lymph node metastasis and overexpression of oncogenes are related events that may affect the prognosis of patient with breast cancer. Sixty-four unselected breast carcinomas
from
paraffin blocks of mastectomy specimens were immunostained for MIBI proliferation associated antigen (Ki-67), cerbB-2 oncoprotein, antigens forestrogen receptor(ER) and progesterone receptor(PR). Immunohistochemical results were compared with
histological findings and clinical data. C-erbB2 protein overexpression was found in 20 cases(31.3%) and associated with a low histological tumor grade(p=0.035), low MIBI labelling index, negative receptor status and younger age(<50) without
statistical
significance. Twenty-one cases(32.8%) demonstrated high grade in MIBI labelling index, and stained in more number of cases of negative receptor status, negative results of c-erbB-2 protein overexpression, younger age, low histological grade and
negative
lymph nodal metastasis without statistical significance. Estrogen receptor status was associated with low histological grade (p=0.02). In many studies, C-erbB-2 protein overexpression had been associated with poor prognosis, high histological
grade,
negative receptor status, high proliferative activity and lymph nodal metastasis. In this study, c-erbB2 overexpression is related with low histological grade and does not associated any other prognostic factors.
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