유방암종에서 있어서 Proliferating Cell Nucleolar Antigen과 Argyrophilic Nucleolar Organizer Region의 분석 -종양 등급관의 상관성에 관하여-
Proliferating Cell Nucleolar Antigen and Argyrophilic Nucleolar Organizer Region in Breast Carcinoma -Correlation with tumor grade-
대한암학회지 1995년 27권 5호 p.730 ~ 737
이호, 이선경, 채우석,
소속 상세정보
이호 ( )
동아대학교
이선경 ( )
동아대학교
채우석 ( )
동아대학교
KMID : 0360319950270050730
Abstract
Authors investigated the expression of proliferationg cell nuclear antigen(PCNA) and the numbers of nucleolar organizer region(NOR) in breast carcinomas correlation with tumor grade. The specimens used in this study were 14 cases of invasive
ductal
carcinomas, 3 cases of invasive carcinomas with predominent intraductal component, 1 case of mucinous carcinoma, 2 cases of invasive papillary carcinomas and 1 case of medullary carcinoma.
All cases were graded using modified grading system according to Bloom and Richardson. The grade, I, Ⅱand Ⅲwere 7 cases, respectively. PCNA was recognized immunohistoche-mically in paraffin sections by the monoclonal antibody PC-10. On the
other
hand,
NOR was demonstrated in paraffin sections using argyrophillic mchod(AgNOR).
The present study showed a significant correlation of PCNA index and of AgNOR number with the histological grade(PCNA: I vs Ⅱ, P<0.05; Ⅱvs Ⅲ, P<0.05 and AgNOR: I vs Ⅱ, p>0.05; Ⅱvs Ⅲ, p>0.05; I vs Ⅲ, p<0.05).
The overall expression of PCNA was significantly correlated with AgNOR number (Spear man rs=0.624, p<005).
On the basis of above findings it was considered that degree of the expression of PCNA and mean AgNOR number may be successefully applied as routine makers to the assessment of the growth potential of breast carcinomas.
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