Human Papillomarirus Type 16 및 18에 감염된 자궁겸부암 환자에서 Proliferating Cell Nuclear Antigen 측정에 관한 연구
The Assessment of Proliferating Cell Nuclear Antigen(PCNA) in Cervical Carcinoma Patients Infected with Human Papillomavirus Types 16 and 18
대한암학회지 1995년 27권 5호 p.773 ~ 782
김지연, 이종훈, 김준범, 최재규,
소속 상세정보
김지연 ( )
건국대학교
이종훈 ( )
건국대학교
김준범 ( )
건국대학교
최재규 ( )
건국대학교
KMID : 0360319950270050773
Abstract
Proliferating cell nuclear antigen (PCNA) is a nuclear protein associated with the cell proliferative state. The relationship between the presence of human papillomavirus (HPV) and proliferative indices (PI) was studied. Determination of PI was
done by
immunohistochemical staining via the avidin-biotin-complex immunoperoxidase method and HPV 16 and HPV 18 status by Southern blot hybridization on paraffin-embedded material from 49 patients with carcinoma of the uterine cervix.
HPV 16 was present in 15 cases, HPV 18 was observed in 6 cases, and both HPV 16 and HPV 18 were found in 4 cases. There was significant correlation between PI and HPV types. PI was 59.7±9.0% in HPV 16 positive lesion, 67.4±10.0% in HPV 18
positive
lesion, 79.4±4.2% in both HPV 16 and HPV 18 positive lesion, and 57.5±16.9% in HPV negative lesion.
Among cervical adenocarcinomas, PI was 72.5±14.9% in HPV 16 or HPV 18positive lesion, as compared to 39.8±15.1% in HPV negative lesion. No correlation was found between HPV-DNA positivity and PI in relation to clinical stages, histologic types,
and
lesion size.
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