다발성골수종 56예의 임상적 분석 및 치료 결과
A Clinical Study on Multiple Myeloma
대한암학회지 1995년 27권 5호 p.869 ~ 878
소속 상세정보
정진우
김정희/김시영/윤휘중/조경삼
KMID : 0360319950270050869
Abstract
Clinical findings and results were analysed in 56 cases diagnosed as multiple myeloma between October 1981 and June 1994 at Kyung Hee University Hospital.
@ES The results were as following:
1) The incidence reached a peak during 7th decade and male to female ratio was 1.2:1.
2) The chief complaints at initial presentation were bone pain(50%), pathologic fracture (14%) and anemia(14%).
3) Hematologic findings showed anemia in 77%, leukopenia in 25% and thrombocytopenia in 23%. ESR was elevated in 91% of patients. Hypercalcemia was noted in 13% and renal failure in 29%.
4) X-ray findings showed pathologic fracture in 39%, osteolytic lesion in 70% and osteoporosis in 32% but normal finding was found in 5% of patients
5) Clinical stage was stage I in 8%, stage Ⅱin 19% and stage Ⅲin 73% of patients. Fifteen of sixteen patients with renal insufficiency were in stage Ⅲ.
6) Serum protein electrophoresis showed a M-peak in 89%. Mean M-protein. Concentration was 4.55g/dl. M-protein was IgG in 57%, IgA in 24%, IgD in 2% and light chain only in 17%. Kappa to lambda ratio was 1.4:1.
7) Variant forms of multiple myeloma were 2 cases of nonsecretory myeloma, 1 cases of solitary plasmacytoma and 1 case of plasma cell leukemia.
8) Response rate to primary chemotherapy was 37% for MP regimen and 60% for M2 regimen. There was statistically significant survival difference between responders and non-responders(p<0.01).
The overall median survival of patients was 76 weeks.
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