담낭암에서 면역조직화학적으로 관찰된 p53 단백 발현
Immunohistochemically Observed p53 Overexpression in Gallbladder Carcinomas
대한암학회지 1995년 27권 6호 p.936 ~ 939
소속 상세정보
이영철
심정원/안혜경/김주섭/최창식
KMID : 0360319950270060936
Abstract
p53 mutations have been known to occur frequently in human cancers, but there have been only a few reports about p53 mutations in gallbladder cancer. Authors observed overexpression of p53 proteins, and investigated the clinical and pathologic
features
in 12 patients of the gallbladder carcinoma. Immunohistochemical staning for p53 proteins was doe by antihuman monoclonal antibody(Pab 1801; pharmingen, CA), and p53 overexpression was found in 75%(nine cases) of 12 resected specimens. When 9
cases
of
p53 overexpression according to extent of involvement were classified, 5 cases belonged to mild ones, 1 case to moderate and 3 cases to severe. And when they were classified according to intensity, 3 cases belonged to mild ones, 2 cases to
moderate
and
4 cases to severe. Probably invasion depth of tumor and extent of differentiation were not related with p53 overexpression. Further study will be necessary why gallbladder carcinoma has higher positivity for p53 proteins.
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