융모상피안 세포주에서 Transforming Growth Factor-B1의 세포 성장 및 c-myc암유전자 발현 억제효과
Inhibitory Effect of Transforming Growth Factor-B1, on Celluiar Proliferation and c-myc Expression in Chorlocarcinoma Cell Line
대한암학회지 1995년 27권 6호 p.961 ~ 967
소속 상세정보
김사진
김진우/나종구/이귀세라/송승규/남궁성은
KMID : 0360319950270060961
Abstract
Modulation of cellular proliferation and c-myc oncogene expression after treatment of human choriocarcinoma cell line(BeWo) with transorming growth factor-β(TGF-β1) have been investigated by MTT [3-4,5-dimethylthiazol-2-yl)-2,
5-diphenyltetrazolium
bromide] assay and northern blotting analysis. TGF-β1 inhibited BeWo cell growth in a dose dependent manner at concentrations of 0.001~10ng/ml. When BeWo cells were exposed to 10ng/ml of TGF-β1, c-myc was repressed after 4hr and completely
abolished
at 24hr of stimulation. These results show that TGF-β1 may play an antiproliferative effect on BeWo cell growth via c-myc gene product. In vitro analysis of cellular and molecular alterations in BeWo cells in this study may aid in elucidating
the
mechanism of action of TGF-β1 on human choriocarcinoma tissues in vivo
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