유방수양암의 임상 및 병리학적 고찰
A Clinicopathologic Analysis of Medullary Breast Cancer
대한암학회지 1997년 29권 3호 p.422 ~ 428
소속 상세정보
장명철/Myung Chul Chang
김지수/윤익진/노동영/윤여규/오승근/최국진/박인애/Jee Soo Kim/Ik Jin Yun/Dong Young Noh/Yeo Kyu Youn/Seung Keun Oh/Kuk Jin Choe/In Ae Park
KMID : 0360319970290030422
Abstract
서론
유방암은 한국 여성에 발생하는 암중 3위를 차지하며, 현재 그 발병율이 증가하는 추세로
근치 절제술과 함께 미용적 수술방법과 보조적 치료의 발달로 좋은 치료성적을 보이고 있
다. 유방 수양 암은 침윤성 유방암의 일종으로 다른 유방암에 비해 예후가 좋은 암으로 알
려져 왔지만 병리조직학적 진단기준이 모호하여 문제점으로 지적되어 왔다. 1977년 Ridolfi
등은 유방 수양암의 정확한 병리조직학적 진단기준을 정의하고 이에 따라 전형적 수양암
(typical medullary cancer), 비전형적 수양암(atypical medullary cancer)과 비수양암
(nonmedullary cancer)으로 분류하였으며 전형적 수양암이 예후가 좋다고 발표하였다. 이에
따라 저자들은 유방 수양암의 병리조직학 및 임상적 특징을 알아보기 위해 본 연구를 시행
하였다.
Purpose : Medullary carcinoma of breast was known to have a better prognosis than
other breast cancer, but the histopathological definition of medullary carcinoma has
varied with time. This study was performed to clarify the clinicopathologic features of
medullary breast.
Materials and Methods : Twenty cases of breast cancer originally were diagnosed as
medullary carcinoma at the Department of Surgery, Seoul National University Hospital
from Jan. 1985 to Jun. 1995. The whole cases were reviewed and reclassified using the
strictly defined histologic criteria applied by Ridolfi et al.
Results : When reclassified, 16 tumors fulfilled the criteria of typical medullary cancer,
But the rest 4 tumors were found to be nonmedullary cancer. The patients ranged from
29 to 69 years in age with an average of 49. The main symptom was the painless
mass. The diameter of the tumor ranged from 1 to 8 cm with a mean size of 2.7 cm.
The axillary lymph node was positive in three cases. The estrogen receptor was
positive in 10%, and the progesterone receptor was positive in 20% of the cases. There
were no local recurrences or distant metastasis during a mean follow-up period of 5.5
years. All patients Survived until the last follow-up.
Conclusion : Medullary breast cancer has good prognosis but strict, uniform
histopathological diagnostic criteria are needed.
키워드
Medullary breast cancer;
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