Cytochrome P45O 2El 효소유전자 다형성분석을 통한 자궁경부암의 유전적 감수성에 관한 연구
Cytochrome P45O 2El Polymorphisms and Genetic Susceptibility to Cervical Cancer
대한암학회지 1997년 29권 3호 p.429 ~ 436
소속 상세정보
김진우
이춘근/손여원/민홍기/이경욱/권녕주/고현숙/신진웅/김흥기
KMID : 0360319970290030429
Abstract
결론
360명의 정상대조군과 228명의 자궁경부암 환자군을 대상으로 자궁암에 대한 유전적 감수
성결정에 기여하는 인자를 규명하기 위해 cytochrome P-450(CYP)효소의 CYP 2E1/PstI 또
는, CYP 221/fso1과 CYP 2E1/RsaaI 다형성등을 분석한 결과 CYP 2El 다형성은 자궁경부
암에 이환될 유전적 감수성 결정에 중요한 역할을 하지 않는 것으로 밝혀졌으며 40세 이하
의 젊은 연령에서 발생하는 자궁경부암의 유전적 감수성에도 관여하지 않는 것으로 나타났
다. 또한, CYP 2El 유전자 다형성은 자궁경부암의 임상병리학적 특성들중 종양의 진행이나
악성도에도 관여하지 않는 것으로 판명되었다.
Purpose : Interindividual genetic differences in susceptibility to chemical carcinogens
are one of the most important host factors in human cancer. The genetically determined
differences in metabolism, related to cytochrome P45O (CYP450) genes have been
reported to be associated with various cancer susceptibility. The present study was set
of to establish the frequency of the polymorphic genotypes of two CYP450 (CYP2E1/PstI
and CYP2E1/Dral) isozymes in Korea, to evaluate a possible increased incidence of the
genotype associated with higher conical cancer risks among Korean cervical cancer
patients.
Materials and Methods : In this study, extracted DNAs from 228 cervical cancer
patients and 360 normal healthy controls were analysed with the polymerase chain
reaction-restriction fragment length polymosphism (PCR-RFLP) method.
Results : In the CYP 2El genotypes, detected by furl or PstI digestion, there were no
statistically remarkable differences between the cervical cancer patients and control
groups. And when the cervical cancer patients were divided into subgroups with respect
to the age, the frequency of CYP 231/Pst1 polymorphisms in the cervical cancer patients
under the 40 years old was not significantly higher compared to the controls or the
patients above the 40 years old and, cl/cl genotype was prominent in this type of
polymorphism. The frequency of CYP 2E1/PstI polymorphisms in the cervical cancer
patients was not significantly higher compared to the controls, and D/D genotype was
prominent in this type of polymorphism. In cervical carcinoma, the polymorphic
genotypes of CYP 2E 1 were not correlated to other parameters including clinical stage,
histological tumor type, and degree of differentiation.
Conclusion : These results suggest that individuals carrying CYP 2E1/PstI (cl/cl) or
CYP 2E1/DraI (D/D) alleles are not genetically susceptible to cervical cancer in Korea.
키워드
Cervical cancer; Genetic susceptibility; Cytochrome P45O 2E 1;
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