Granisetron과 Dexamethasone 병행 요법의 지연성 오심 및 구토에 대한 효과
Effect of Granisetron Plus Dexamethasone in the Prevention of Delayed Nausea and Vomiting
대한암학회지 1997년 29권 4호 p.690 ~ 699
소속 상세정보
심정우/Jeong Woo Shim
이용섭/김흥업/정경원/박영호/장세호/황진용/장정순/이종석/Yong Seop Lee/Heung Up Kim/Geong Won Jung/Yeong Ho Park/Se Ho Chang/Jin Yong Whang/Jeong Soon Jang/Jong Seok Lee
KMID : 0360319970290040690
Abstract
결론
본 연구 결과 고형암으로 고용량의 cisplatin을 포함한 복합 화학요법을 받은 64명의 환자
를 대상으로 시행한 granisetron과 dexamethasone의 지연성 오심 및 구토에 대한 예방 효
과는 다음과 같다. 지연성 오심에 있어서 37예(58%)에서, 지연성 구토에 있어서는 54예
(84%)에서 효과가 있었다. 또한 ECOG performance scale이 좋은 경우와 급성 오심 및 구
토가 잘 조절된 경우 지연성 오심 및 구토의 조절 효과가 더 좋았다. Granisetron과
dexamethasone의 병용 요법은 1회의 고용량의 cisplatin을 투여 받는 환자들에게 특별한 부
작용 없이 급성 오심뿐 아니라 지연성 오심 및 구토에도 많은 도움이 될 것으로 사료된다.
#초록#
Background: Granisetron, a new 5-HT3 receptor antagonist, was reported
as a highly effective antiemetics, especially in combination with dexamethasone, in the
prevention of acute emesis induced by cisplatin. But there is lack of data about
effectiveness in the prevention of delayed emesis. In this study, the efficacy of
granisetron plus dexamethasone in the prevention of delayed emesis induced by cisplatin
was evaluated.
Materials and Methods: Sixty-four patients who were to receive high-dose cisplatin
containing chemotherapy regimen were enrolled in this study. They were received 20 mg
of dexamethasone and 3 mg of granisetron at 30 min and 10 minutes prior to cisplatin
infusion, respectively. They were monitored for 5 days, first 24 hours for acute
nausea/vomiting and the subsequent 4 days for delayed nausea/vomiting. Antiemetic
effect of granisetron was evaluated according to the criteria of Italian Group of
Antiemetic Research.
Results: Control of delayed nausea and vomiting was achieved in 58% and 84%,
respectively. Eastern Cooperative Oncology Group performance status was a statistically
significant prognostic factor for control of acute vomiting and delayed nausea/vomiting.
There were no stastically significant differences between control of delayed
nausea/vomiting and other prognostic factors, including sex, age, and prior history of
cisplatin therapy. The antiemetic effect was greater in the patients who had controled
acute nausea/vomiting than those who had not.
Conclusion: Granisetron plus dexamethasone is an excellent regimen in the control of
not only acute emesis but also delayed emesis induced by high-dose cisplatin
chemotherapy.
키워드
Granisetron; Dexamethasone; Cisplatin; Emesis; Serotonin;
원문 및 링크아웃 정보
등재저널 정보