유방암에서 Phospholipase Cγ-1, Epidermal Growth Factor Receptor 및 Her-2/neu 발현 양상에 관한 연구
Value of Phospholipase Cγ-1, Epidermal Growth Factor Receptor, and Her-2/neu in Human Breast Cancer
대한암학회지 1997년 29권 5호 p.724 ~ 737
소속 상세정보
정기훈/Ki Hoon Jung
배성한/이은숙/배정원/구범환/김인선/황정웅/Sung Han Bae/Eun Sook Lee/Jeoung Won Bae/Bum Whan Koo/In Sun Kim/Cheung Wung Whang
KMID : 0360319970290050724
Abstract
결론
결론적으로 면역조직화학염색법을 이용한 PLCγ-1, EGFR및 Her-2/neu단백 발현 여부의
관찰은 전체 생존율 및 비재발 누적 생존율과 PLCγ-1, EGFR 및 Her-2/neu 단백 발현과
유의한 차이를 보여 유방암 수술 후 예후 예측에 유용하게 이용될 수 있을 것으로 사료되
며, 이들은 각각이 독립적인 예후 인자로서 뿐만 아니라 서로 병합하여 사용하면 좋은 예후
인자가 될 것으로 생각된다.
#초록#
Purpose : Oncogen or growth factor receptor such as phospholipase C isoenzyme γ-1
(PLC γ-1), epidermal growth factor receptor (EGFR), and Her-2/neu which related with
tyrosin kinasemay and then regulating yell proliferation may have a role as prognostic
factors for breast cancer.
Material and Methods : With assumption that expression of PLC γ-1, EGFR and
Her-2/neu oncogene has close relationship with prognosis of breast cancer, 59 breast
cancer patients who were operated upon at Korea University Hospital during a period of
6 years starting June 1988 to May 1994 were selected for this study. This study was
carried out by comparing between expression of PLC γ-1, EGFR and Her-2/neu
oncogene and patient's survival rate. These expression were also compared with TNM
system, estrogen and progesterone receptor and at same time these expressions were
compared with each other to see whether there are any relationship among these
expression.
Results : Expression of PLC γ-1, EGFR and Her-2/neu were present in 42% (25/59),
46% (27/59) and 20%(12/59). The expression of PLC γ-1 was closely related with the
expression of EGFR(p<0.05) and Her-2/neu (p<0.05), but there were no relationship
between the expression of PLC γ-1 and hormonal receptors and TNM stage(p>0.05).
The expression of EGFR was closely related with the expression of Her-2/neu(p<0.05)
and hormone receptors(p<0.05), but there were no relationship between the expression of
EGFR and pathologic TNM stage(p>0.05). The expression of Her-2/neu was not closely
related with hormone receptors and TNM stage except axillary lymph node metastasis.
There were close relationship between overall and disease free survival and PLC γ-1
and Her-2/neu. But EGFR had only related with disease free survival rate.
Conclusion : In conclusion, the expression of PLC γ-1, EGFR and Her-2/neu
oncogene in human breast cancer may be useful prognostic factors independently and it
may potentiated its individual value as a prognostic factors if use them together.
키워드
Breast cancer; PLC γ-1; Her-2/neu and EGFR;
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