유방 수양암의 재분류 및 임상적 특성에 관한 고찰
Reclassification of the Medullary Carcinoma and It
대한암학회지 1997년 29권 5호 p.748 ~ 753
소속 상세정보
김상규/Sang Kyu Kim
손창용/강구정/김유사/장은숙/Chang Yong Sohn/Koo Jeong Kang/You-Sah Kim/Eun Sook Chang
KMID : 0360319970290050748
Abstract
결론
수양암으로 진단된 37예를 재검사하여 Typical medullary carcinoma 2211 (60%),
Atypical medullary carcinoma 12예(32%)로 진단되었으며 Typical medullary carcinoma는
전체 유방암의 3.1%를 차지하였다. 전체 유방암과 비교하여 환자의 평균 연령, 종양의 크기
및 임파절 전이에서는 큰 차이가 없었고 Typical medullary carcinoma의 5년 생존율은
95.5%로 전체 유방암보다 높게 나타났다.
#초록#
Purpose : Reclassification of the medullary carcinoma using a strict histologic criteria
and analysis of the clinical and pathological characteristics of the medullary carcinoma.
Material & Methods : Thirty-seven cases of the breast carcinoma originally diagnosed
as medullary carcinoma were reviewed. One to ten microscopic slides of each case were
reexamined and reclassified using the strictly defined histologic criteria defined by
Ridolfi et al. Tumors were excluded from the category of the typical medullary
carcinoma(TMC) on the basis of presence of glandular features, focal marginal
infiltrations, or sparse mononuclear infiltrations. Tumor with two or more atypical
features, or extensive marginal infiltrations, no mononuclear cell infiltration and/or less
than 75% syncytial growth were classified as infiltrating ductal carcinoma with
medullary feature(IDC). A predominantly syncytial growth pattern (75% or more) was
requisite for inclusion in both TMC and atypical medullary carcinomas(AMC).
Results : Twenty-two tumors (60%) fulfilled the criteria for TMC, and 12 tumors
(32%) were AMC and three tumors (8%) were IDC. TMC occupied 3.1% of breast
cancer. The mean age of patients with TMC was 45.4±11.2 years an4 the average size
of the tumor in TMC was slightly larger than that of breast cancer in general, although
not statistically significant. The frequency of lymph node metastasis in TMC was
similar to breast cancer in general. Five year survival of patients with TMC was 95.5%
which was significantly better than breast cancer in general.
Conclusion : The TMC occupied 3.1% of breast cancer. The mean age of patient,
tumor size and lymphnode metastasis were not different from that of breast cancer but
5 years survival of patient with TMC was significantly better than breast cancer in
general.
키워드
Typical Medullary Carcinoma; Breast;
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