위암 환자의 혈액 및 조직에서 Urokinase-type Plasminogen Activator 발현의 임상적 의의
Clinical Significance of Urokinase-type Plasminogen Activator(uPA) Expression from Serum and Tissue of Gastric Cancer Patients
대한암학회지 1997년 29권 5호 p.765 ~ 773
소속 상세정보
정현철/Hyun Cheol Chung
KMID : 0360319970290050765
Abstract
결론
위암조직에서 uPA, PAI-1은 병기 I에서부터 증가하였으며, 말초혈액의 uPA 값은 암조직
의 uPA값과 상관성이 관찰되었다. 그리고 위 절제전 간문맥의 uPA와 말초혈액의 uPA값
사이에, 위암조직의 PAI-1/uPA 비와 말초혈액의 PAI-1/uPA 비 사이에서 상관성이 관찰되
어, 단순한 uPS와 PAI-1의 측정보다는 혈액에서 이들의 비 혹은 불균형을 조사함이 보다
조직에서의 발현 및 불균형을 예측할 수 있을 것으로 판단되었다.
#초록#
Purpose : We measured the gastric cancer tissue uPA and plasminogen activator
inhibitor-1 (PAI-1) levels and compared them to those of the peripheral and portal blood
levels to evaluate the correlation.
Materials and Methods : Tissue uPA and PAI-1 levels were measured by ELISA
assay (Monozyme, Netherland) in paired 85 normal and cancer tissues resected from
gastric cancer patients. In 50 patients, blood uPA and PAI-1 levels were measured from
preoperative peripheral and portal blood, post-operative portal blood.
Results : Gastric cancer tissue uPA and PAI-1 levels increased from the early stage.
The elevated cancer-to-normal ratios of the uPA and PAI-1 were constant from stage
Ⅰ to Ⅳ. There were correlations of uPA between normal and cancer
tissues(r2=0.38) and between peripheral and pre-resection portal blood
level(r2=0.64). There were no correlations between tissue PAI-1 level and
blood PAI-1 levels. However, there were correlations in PAI-l/uPA ratio between cancer
tissue and peripheral blood(r2=0.25), peripheral blood and preresection portal
blood(r2=0.60).
Conclusion : Even if the cancer tissue levels of uPA and PAI-1 increased from the
early stage of gastric cancer, only blood uPA level correlated with tissue uPA level. A
modest correlation found in PAI-1/uPA ratio between cancer tissue and blood suggests
applicability of blood PAI-1/uPA ratio in predicting tissue uPA, PAI-1 expression.
키워드
uPA; PAI-1; Gastric cancer; Serum; Tissue;
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