Medulloblastoma/PNET에서의 p53 단백질 발현 양상에 관한 연구
Immunohistochemical Study on Expression of the p53 Protein in Medulloblastoma/PNET
대한암학회지 1997년 29권 5호 p.867 ~ 873
소속 상세정보
김은정/Eun Jung Kim
KMID : 0360319970290050867
Abstract
결론
1988년부터 1995년까지 medulloblastoma/PNET로 진단받은 24예를 대상으로 면역조직화
학적 염색법을 통하여 p53 단백질의 발현에 관한 연구를 실시한 결과 p53 단백질의 발현빈
도는 25%이었다. 그리고 p53 단백질의 발현이 종양의 크기나 조직학적 세포분화도 및 재발
여부와는 상관관계가 없었으나, 진단 당시의 전이유무와는 밀접한 상관관계가 있었으므로
향후 medulloblastoma/PNET환자에서 진단당시에 p53 단백질의 발현 유무를 알아봄으로써
전이유무의 확인에 도움이 될 것으로 생각된다.
#초록#
Purpose : The present study explores the expression rate of p53 mutation and the
correlation between the expression of p53 protein and prognostic factors in
medulloblastoma/PNET (primitive neuroectodermal tumor).
Materials and Methods : We studied retrospectively 24 patients with
medulloblastoma/PNET, who were admitted in Dong-A University Hospital, Pusan
National University Hospital and Inje University Pusan Paik Hospital from 1988 to 1995.
Detection of p53 mutations was made by immunohistochemical staining of p53 protein on
paraffin- embedded tissues. The correlation between the expression of p53 protein and
prognostic factors was evaluated by the Spearman correlation analysis.
Results : p53 protein was expressed in 6 of 24 patients(25%). In 20 patients who
could be evaluated for metastasis, 16 patients of M0, 1 Patient of
M1 and 3 patients of M2 were grouped by M stage, and the
expression of p53 was detected in 1 of 16 M0 group(6.3%) and 3 of 3
M2 group(100%). p53 expression was significantly related to the M stage
of medulloblastoma/PNET(r=0.73, p<0.001). The detection of p53 was not significantly
associated with T stage, cellular differentiation and the relapse rate of
medulloblastoma/PNET
Conclusion : The immunohistochemical detection rate of p53 protein in
medulloblastoma/PNET was 25%. The expression of p53 protein was significantly related
to the M stage, with higher expression rate in M2 group of medulloblsatoma/PNET.
키워드
Medulloblastoma; Primitive neuroectodermal tumor; Immunohistochemical stain; p53;
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