만성림프구성백혈병의 임상적 고찰
A Clinical Study on Patients with Chronic Lymphocytic Leukemia
대한암학회지 1997년 29권 6호 p.1106 ~ 1113
소속 상세정보
양전호/Jeon Ho Yang
신현수/정영식/황준호/신동건/손상균/이규보/황기석/Hyeon Soo Shin/Young Sik Jung/Jun Ho Whang/Dong Gun Shin/Sang Kyun Sohn/Kyu Bo Lee/Kee Suk Whang
KMID : 0360319970290061106
Abstract
서론
만성림프구성백혈병(Chronic lymphocytic leukemia, CLL) 은 혈액, 골수, 임파선, 비장 등
에서의 악성 B 림프구의 클론성 증식과 축적을 특징으로 하며 서구에서는 가장 흔한 백혈
병의 한 형태이나 국내에서는 백혈병 환자 중 0.4∼1.7% 만을 차지하는 비교적 드문 질환으
로 보고되고 있다.
CLL은 다양한 임상증상 및 경과를 취하는 질환으로 최근 서구에서는 CLL에 대한 생물
학, 자연경과, 치료에 대한 많은 발전이 있어왔으나 국내에서는 적은 수의 환자로 인하여 포
괄적인 연구가 없는 상태이다. 이에 저자들은 말초혈액도말 및 골수생검에 의해 CLL로 진
단 받은 17예를 대상으로 임상상을 분석하여 서구의 경우와 비교, 검토하여 문헌고찰과 함
께 보고하는 바이다.
#초록#
Purpose : Chronic lymphocytic leukemia(CLL) is the most common form of leukemia
in western countries but it has been reported rarely in Korea. The purpose of this study
was to evaluate the clinical characteristics, treatment responses and prognosis of the
patients with CLL.
Materials and Methods : We retrospectively reviewed the medical records of 17
patients with CLL diagnosed at the Catholic University of Taegu-Hyosung &
Kyungpook National University Hospital from Jan. 1986 to Mar. 1996.
Results : There were 9 males and 8 females and the mean age was 55 years. The
majority of patients had systemic symptoms(77%) and advanced clinical stage(Binet
stage C, 70%) at the time of diagnosis. The bone marrow histology was reviewed in 13
cases and patients were subdivided into those with a diffuse(9cases) and
nondiffuse(4cases) pattern of bone marrow histology. In patients with advanced clinical
stage, diffuse pattern was predominated and showed poor survival. 14 patients were
treated with chlorambucil/steroid or combination chemotherapy. Among the 13 evaluable
patients, 1(8%) achieved a complete response and 7(54%) achieved partial responses, and
median survival duration was 18months. 11 patients died after 2∼18 months of
follow-up and infection was the main cause of death.
Conclusion : Poor prognostic factors, such as high blood lymphocyte counts, diffuse
bone marrow involvement pattern & advanced clinical stage, are common in our patients
at presentation 6: showed poor survival.
키워드
Chronic lymphocytic leukemia;
원문 및 링크아웃 정보
등재저널 정보