조기대장암종에서 미세혈관밀도와 p53단백의 과발현에 관한 연구
in Early Colorectal Cancer
소속 상세정보
김영민/Young Min Kim
강경훈/양석균/유창식/김진천/Gyeong Hoon Kang/Suk Kyun Yang/Chang Sik Yu/Jin Cheon Kim
KMID : 0360319980300010080
Abstract
결론
조기 대장암에서 p53면역조직화학 염색을 시행하여 60%의 양성을 보여 기왕의 보고들과
유사한 발현율을 보였다. 점막 종양군보다는 점막하 층 종양군의 p53단백 과발현이 높았으
며, 발생부 위별 p53단백 과발현은 타부위에 비해 S-결장에서 의의 있게 높았다. 분화도에
따른 p53단백 과발현은 고분화보다는 저분화를 보이는 종양에서 높게 나타났다. factor Ⅷ
면역조직화학 염색을 시행하여, 평균 신생혈관 수는 점막하층 종양군이 점막군보다 높았으
나 통계학적 의의는 없었다. S-결장의 경우 직장이나 기타 다른 부위보다 신생 혈관형성이
의의 있게 높았으나 그 의의에 대하여는 연구의 보완이 필요하리라 생각된다. p53양성 군에
서 음성군보다 신생혈관형성이 높았지만 통계학적 의미는 얼었기 때문에 p53단백 과발현과
신생혈관형성의 관련성은 명확하지 않다.
Purpose : Angiogenesis, playing a critical role in tumor growth, development, and
metastatic process, is alleged to be related to the prognostic factors and patient's
survival of the colts-rectal cancer. The p53 gene, present in short arm of chromosome
17, is involved in multistep cole-rectal carcinogenesis. The correlation of p53 gene and
angiogenesis has been recently reported. So, we designed to assess the rate of p53
overexpression, the prognostic significance of microvessel count, and the relationship of
p53 overexpression and angiogenesis in early colts-rectal cancer(ECC) patients.
Material and Methods : The study material included 68 ECC from 65 patients, 40
mucosal (m-ECC) and 28 submucosal ECCs (sm-ECC). Immunostainings against p53
and factor Vlll-related antigen were done and the results were analyzed with respect to
tumor depth, site, and differentiation. And also the correlation between p53
overexpression and microvessel counts(MVC) was performed.
Result : The rate of p53 overexpression was higher in sm-ECC than in m-ECC (p <
0.05). The rate of p53 overexpression was highest in sigmoid colon and statistically
significantly different compared with other sites. The differentiation of the tumor was
closely correlated with p53 overexpression and the poorer the differentiation, the more
overexpression of p53 (p <0.05). There was no significant difference between MVCs of
m-ECC and sm-ECC (27.2±5.5 and 29.8±6.0, respectively). However, MVC were higher
in sigmoid colon than in any other sites (p <0.05). MVC did not show significant
correlation with tumor differentiation or p53 overexpression.
Conclusion : These data indicate that p53 overexpression is correlated with tumor
depth and differentiation but not MVC. The significance of higher MVC and p53
overexpression in sigmoid colon are reserved for further studies.
키워드
Depth; Differentiation; Early colorectal cancer; p53; Microvessel count;
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