전이성 혹은 재발성 위암에 대한 FPL(5-Flurouracil/Cislatin/Levamisole) 복합 화학요법의 치료 효과
FPL(5-Fluorouracil, Cisplatin, Levamisole) Combination Chemotherapy for Metastatic or Recurrent Gastric Carcinoma
대한암학회지 1998년 30권 2호 p.272 ~ 278
소속 상세정보
고병성/Byung Seong Ko
이기형/최강현/박선미/윤세진/김승택/Ki Hyung Lee/Kang Hyeon Choe/Seon Mee Park/Sei Jin Youn/Seung Taik Kim
KMID : 0360319980300020272
Abstract
결론
전이성 혹은 재발성 위암에 대한 FPL 항암요법은 기존의 FP 화학요법에 비해서 관해율
및 관해지속 기간에 있어서 비슷한 결과를 나타냈으며 환자들의 생존기간에 있어서는 다소
우수한 결과가 관찰되었다. 그러나 FP 요법에 비해서 다소 높은 골수 부작용이 관찰되어
고령자나 골수 침범이 있는 환자에게서는 주의를 요할 것으로 사료된다. 치료효과 및 부작
용의 직접적인 비료를 위해서는 제 3상 비교 연구가 필요할 것으로 사료된다.
#초록#
Purpose : FP(5FU, Cisplatin) Combination is one of the most active regimen for the
advanced gastric cancer with a response rate of 50-60%. In spite of this high response
rate, there is little evidence that FP regimen results in survival benefit for patients with
advanced gastric cancer. This study was performed to evaluate the efficacy and toxicity
enhancing the antitumor effects of 5-FU in other cancer.
Materials and Methods : Previously untreated patients with metastatic or recurrent
gastric cancer were treated with 5-FU(1000mg/M2 civ, D1-5),
cisplatin(60mg/M2 iv, D1) every response rate, response duration, and
toxicities.
Results ; Between June 1992 and Aug. 1996, thirty three patients were included in this
study. Patients received 2-18 cycles of chemotherapy(Median 5). Among the evaluable
31 patients, 18 patients(58%, 95% C.I 40.4-75.7) showed objective response including
one(3.2%) clinical complete response, The median response duration was 7.7month(95%
leucopenia were observed. There was no death from concurrent infection.
Conclusion : FPL combination therapy is as effective as conventional FP
chemotherapy, but resulted in somewhat more myelosuppression.
키워드
FPL; Levamisole; Gastric cancer;
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