대장암을 동반한 다발성 원발성 악성종양
Multiple Primary Malignant Neoplasm with Colorectal Cancer
대한암학회지 1998년 30권 4호 p.668 ~ 674
소속 상세정보
김희철/Hee Cheol Kim
김창남/정춘식/유창식/김진천/Chang Nam Kim/Chun Sik Jung/Chang Sik Yu/Jin Cheon Kim
KMID : 0360319980300040668
Abstract
서론
최근 암의 조기발견, 치료법의 발달과 함께 환자의 장기 생존이 늘어나면서, 환자의 잔여
생존기간 중 새로운 원발성 암이 발생할 가능성이 증가하고 있다.
다발성 악성종양이 호발되는 조건이나 인자 등은 아직 잘 알려져 있지 않으나, 이에 대한
규명은 암 발생에 관여하는 요인의 하나를 밝히는 전제가 될 수 있을 것이다. 대장암의 발
생은 유전자적인 변이나, 식이 등 환경적 요인이 작용한다고 알려져 있다. 대장암을 동반하
는 다발성 원발성 악성종양으로부터 대장암과의 관련성을 분석함으로써 대장암의 진단, 치
료 및 추적 시 유의할 사항 및 암발생의 원인 규명을 위한 향후 방향을 모색하고자 하였다.
Purpose: The incidence of multiple primary malignant neoplasm has increased in
recent decades. The etiologies and epidemiologies of multiple primary malignant
neoplasm are still remained to be verified. A group of patients with multiple primary
malignant neoplasms accompanied by colorectal cancer was analyzed to determine the
relationship between certain cancers and colorectal cancer.
Materials and Methods: From Jan. 1989 to Jun 1997, there were 56 patients with
colorectal cancers accompanied by cancers of another organs. The retrospective analysis
was done on the basis of cancer origin and intervals between the cancers.
Results: The male-to-female ratio was 25 to 31. The characteristics of colorectal
cancers in multiple primary malignant neoplasm were similar to the colorectal cancers
without other cancers. Among 56 patients, 50 patients had the double primaries and 6
had the triple primaries. In the patients with double primaries, extracolonic cancers were
found in the stomach(16), hepatobiliary system(12), urologic system(6), gynecologic
organ(6) and others. In the patients with triple primaries, extracolic cancers were found
in the stomach(5), uterus(2), lung(2) and others. The patients with family history of
malignancy were 10 cases and the rate in the triple primaries seemed to be higher than
double primaries.
Conclusion: It could be desirable to follow-up and work-up the patients with
colorectal cancer keeping in mind that the malignancy in other organs especially
stomach might be present.
키워드
Colorectal cancer; Multiple primary neoplasm;
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