침윤성 소엽유암의 임상적 고찰
A Clinical Study of Infiltrating Lobular Breast Cancer
소속 상세정보
김중모/Jung Mo Kim
김영철/노동영/윤여규/오승근/최국진/Young Chul Kim/Dong-Young Noh/Yeo-Kyu Youn/Seung Keun Oh/Kuk Jin Choe
KMID : 0360319990310010090
Abstract
서론
유방암은 한국 여성에 발생하는 암중 3위를 차지하며, 우리나라에서 유암은 발생이 계속
증가되어 왔으며, 질병의 발생 형태가 서구와 비슷하여 지고 있다고 볼 때 앞으로도 유암의
빈도는 계속 증가되리라고 예상된다. 침윤성 소엽유암은 흔히 경계가 불분명한 종괴를 주소
로 내원하며, 다발성 및 양측성 병변을 지니는 경우도 많다. 그러나 유관암에 비해 상대적으
로 빈도가 적기 때문에 흔히 경험하는 암종은 아니다. 이에 따라 저자들은 침윤성 소엽유암
의 임상적 양상과 조직병리학적 특징을 살펴보고, 이 환자군의 예후를 살펴보고자 한다.
Purpose: Infiltrating lobular carcinoma of the breast was blown to have a high
incidence of multicentricity and bilaterality in patients. We analyzed the clinical features
of infiltrating lobular breast cancer.
Materials and Methods: We studied 29 patients with infiltrating lobular carcinoma of
the breast, from Jan. 1980 to Mar. 1997 in the Department of Surgery, Seoul National
University Hospital.
Results: The age of the patients ranged from 32 to 71 years with an average of 45.2
years. The main complaining symptom was a painless mass. The diameter of the tumor
ranged from 0.7 to 7 ㎝ with a mean size of 2.8 ㎝. The axillary lymph node was
positive for malignancy in 12 cases. The number of multicentric breast cancers were 7
cases (241%), and the number of bilateral breast cancers were 3 cases (10.3%). The
estrogen receptor was positive in 66.7%, and the progesterone receptor was positive in
75% of the cases. There were one local recurrence and three distant metastases during
a mean follow-up period of 4.5 years. The 5-year survival rate and 5-year disease free
survival rate were 89.6% and 88.6%, respectively.
Conclusion: Infiltrating lobular breast cancers are at greater risk of developing
multicentricity and bilaterality than nonlobular breast cancers. Careful program of
frequent follow-up examinations and thorough histopathological studies are needed for
patients with infiltrating lobular breast cancers.
키워드
Infiltrating lobular breast cancer;
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