복강내 및 후복막강 육종
Intraperitoneal and Retroperitoneal Sarcomas
대한암학회지 1999년 31권 1호 p.173 ~ 179
소속 상세정보
정영욱/Young Wook Jung
노우철/문난모/백남선/이종인/최동욱/방호윤/Woo Cheol Noh/Nan Mo Moon/Nam Sun Park/Jong Inn Lee/Dong Wook Choi/Ho Yoon Bang
KMID : 0360319990310010173
Abstract
서론
연부조직 육종의 빈도는 모든 악성 종양의 1%이하이며 특히 복강내 및 후복막강 육종은
각각 전체 육종의 4%, 15% 정도를 차지하는 비교적 드문 종양중의 하나이다. 대부분의 복
강내 및 후복막강 육종은 증상이 비특이적이며 종양이 커진후에 발견되고 진단 당시 원격
전이가 있는 경우가 많다. 복강내 및 후복막강 육종의 치료는 외과적인 절제가 가장 중요하
며 보조요법으로 시행하는 화학요법과 방사선 치료의 효과는 아직 입증되어 있지 못한 실정
이다.
저자들은 복강내 및 후복막강 육종의 임상 병리학적 분석과 재발에 영향을 주는 인자를
찾아내어 향후 이들 종양의 치료 방침을 세우는데 도움이 되고자 하였다.
Purpose: Sarcomas arising in intraperitoneal cavity and retroperitoneal space are
relatively uncommon. Thus, studies characterizing the results of long-term follow-up are
limited. The purpose of this study was to identify the clinicopathologic features and
prognostic factors of intraperitoneal and retroperitoneal sarcomas.
Materials and Method: Thirtyeight patients with intraperitoneal or retroperitoneal
sarcoma who had been treated at Department of Surgery, Korea Cancer Center Hospital
during the period from January 1987 to December 1997 were reviewed retrospectively.
Results: The ratio between male to female was 0.9 : 1. The mean age of the patients
was 48.3 (32∼75) years. The most common symptom was abdominal pain or discomfort
(61%), followed by palpable mass (55%), GI bleeding (34%), weight loss (26%), and
change of bowel habits (21%). The most common histologic type was leiomyosarcoma
(73.7%), followed by liposarcoma (23.7%), and malignant fibrous histiocytoma (2.6%).
The mean tumor size was 15.5×12.1×8.7 ㎝. Among 38 cases, 25 cases developed in
intraperitoneal cavity and 13 cases arose in retroperitoneal space. Overall, 44 operations
were performed in 31 patients. Among them, complete surgical resection constituted
73%. In 20 cases, combined resection of adjacent organ was performed to accomplish
complete surgical resection of tumors. During the median follow up period of 23 months
(3∼116 months), the overall 5-year survival rate was 34.7%. The patients who had been
treated by complete surgical resection showed better survival than those in whom
palliative resection or biopsy only was performed (38.6% vs 0% of 5 YSR, p=0.015).
Liposarcoma showed better prognosis than leiomyosarcoma (41.7% vs 34.2% of 5 YSR,
p=0.0000). The size of tumor (10 ㎝>vs 10 ㎝≤) was not a statistically significant
prognostic factor.
Conclusion: In this series, The histologic type and complete surgical resection were
important factors that can affect the survival of the patients. Aggressive surgical
resections are therefore warranted to obtain better outcome of the patients with
intraperitoneal and retroperitoneal sarcomas.
키워드
Sarcoma; Intraperitoneal; Retroperitoneal;
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