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35¼¼ ÀÌÇÏ ¿©¼ºÀÇ À¯¹æ¾Ï The Breast Cancers in Women Less Than 36 Years of Age

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À̺´Âù/Byung Chan Lee ±è¼¼Áß/ÀÌ¿ìÁ¤/¹®´öÁÖ/ÀÌ°æ½Ä/Sei Jung Kim/Woo Jung Lee/Duk Joo Moon/Kyong Sik Lee

Abstract

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Purpose : There is still much controversy about the prognosis of breast cancer
developed in young women compared with old women. We performed this study to
evaluate the prognosis of the breast cancer in young women.
Material and Methods : From 1985 to 1994, 1189 women received operations for breast
cancers at Severance Hospital. The study group included patients less than 36 years old
who had unilateral, invasive and primary operable breast cancers (N=158). The control
groups included patients between 36 and 50 years old (N=518) and those between 51
and 65 years old (N=269) who had the same conditions as the study group. The 5-year
survival and 5-year disease-free survival rate for three groups were compared using
Kaplan-Meier method and Log-rank method. To evaluate the age as an independent
prognostic factor in premenopausal women Cox's proportional hazard model was used.
Result : The overall 5-year survival rate and 5-year disease-free survival rate of the
study group were significantly lower than those of control groups (p<0.05). There was
no significant difference in 5-year survival and 5-year disease free survival between the
two control groups. The Cox's propotional hazard model analysis revealed that the stage
is the most important prognostic factor and the age was also an independent prognostic
factor.
Conclusion : The prognosis of breast cancer less than 36 year old was poorer than
that of 36¡­51 year old and 51¡­65 year old, suggesting that the age may be an
independent prognostic factor in premenopausal women. More aggressive adjuvant
treatment is required for breast cancer patients less than 36 year old of age.

Å°¿öµå

Breast cancer; Young women;

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