위선암종의 진행과 금속의존성 기질분해효소의 상관성
Interrelation between the Progression of Gastric Adenocarcinoma and the Matrix Metalloproteinases
대한암학회지 2000년 32권 3호 p.497 ~ 505
임성철, 이미자, 박찬국,
소속 상세정보
임성철 ( Lim Sung-Chul )
조선대학교 의과대학 병리학교실
이미자 ( Lee Mi-Ja )
조선대학교 의과대학 병리학교실
박찬국 ( Park Chan-Guk )
조선대학교 의과대학 내과학교실
KMID : 0360320000320030497
Abstract
Purpose :An essential element in tumor invasion and metastasis in the degradation of extracellular matrix in matrix Metalloproteinases (MMPs). But little is known about the role of them in the gastric adenocarcinoma. The purpose of this study was to determine whether human gastric adenocarcinoma expressed MMPs and whether MMPs were concerned in tumor stage and histologic subtypes.
Materials and Methods : The authors performed the retroactive analysis in 38 cases of early gastric carcinoma (EGC) and 61 cases of advanced gastric carcinoma (AGC), including 38 cases of diffuse type and 61 cases of intestinal type, using immunohistochemical staining for MMP-2, -3 and -9.
Results :MMP-2, -3 and -9 were localized to neoplastic cells in 93% (92/99 ), 32% (32/99) and 76% (76/99), respectively. MMP-2 and -9 were found mainly in tumors of intestinal type and less frequently in those of diffuse type. There were positive correlation between the presence of MMP-2 and -9 and lymph node metastasis. There was positive correlation between MMP-2 expression and tumor stage.
Conclusion :The authors demonstrated a statistically significant expression of tumoral MMP-2, -3 and -9 in gastric adenocarcinoma and their correlation with tumor progression. This study also suggests that the presence of MMP-2 and/or -9 is a useful indicator for poor prognosis.
키워드
Stomach neoplasm;Matrix metalloproteinase;
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