진행성 위암에 대한 5-Flurouracil (5-FU) 5일 지속주입 및 Cisplatin 복합화학요법: 5-FU 혈중농도 측정의 의의
Chemotherapy with Five-Day Continuous Infusion of 5-Fluorouracil (5-FU) Plus Cisplatin for Advanced Gastric Cancer: Significance of 5-FU Concentration Monitoring
대한암학회지 2000년 32권 3호 p.516 ~ 523
박연희, 김봉석, 류백열, 김태유, 임영혁, 신호상, 강윤구,
소속 상세정보
박연희 ( Park Yeon-Hee )
원자력병원 내과
김봉석 ( Kim Bong-Seog )
원자력병원 내과
류백열 ( Ryoo Baek-Yeol )
원자력병원 내과
김태유 ( Kim Tae-You )
원자력병원 내과
임영혁 ( Im Young-Hyuck )
원자력병원 내과
신호상 ( Shin Ho-Sang )
공주대학교 환경교육과
강윤구 ( Kang Yoon-Koo )
원자력병원 내과
KMID : 0360320000320030516
Abstract
Purpose :To investigate the therapeutic effects and toxicities of 5-day continuous infusion of 5-FU plus cisplatin FP chemotherapy in advanced gastric adenocarcinoma and to elucidate the relationship between the pharmacokinetic (PK) parameters and therapeutic outcome.
Materials and Methods :Patients with previously untreated advanced stomach cancer were treated with FP chemotherapy. Plasma concentrations of 5-FU were measured using gas chromatography method for 5 days. Correlation of PK parameters of 5-FU with clinical outcome after FP chemotherapy was studied.
Results : Response rate of FP chemotherapy was 46% (95% C.I.: 30 ∼62%). There was a wide range of difference in the concentration and area under the curve (AUC) of 5-FU from patients to patient. We could find significant differences in AUC of 5-FU between the responders and the non-responders (p<0.05).
Conclusion :We could confirm that FP chemotherapy was effective and tolerable for the treatment of advanced stomach cancer. The monitoring of plasma 5-FU concentration after chemotherapy and the adjustment of subsequent 5-FU dose seems to be necessary to improve the treatment outcome of FP chemotherapy.
키워드
Stomach neoplasm;Contrinuous infusion;5-FU;Pharmacokinetics;
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