조기위암에서 Vascular Endothelial Growth Factor와 basic Fibroblast Growth Factor의 발현
Vascular Endothelial Growth Factor and basic Fibroblast Growth Factor Expression in Early Gastric Carcinomas: Correlation with Clinicopathologic Factors
대한암학회지 2000년 32권 6호 p.989 ~ 996
김영식, 조현득, 박성환, 김대원, 김대수, 최종상, 오화은,
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김영식 ( Kim Young-Sik )
고려대학교 의과대학 병리학교실
조현득 ( Cho Hyun-Duk )
고려대학교 의과대학 병리학교실
박성환 ( Park Seong-Hwan )
고려대학교 의과대학 병리학교실
김대원 ( Kim Dae-Won )
고려대학교 의과대학 병리학교실
김대수 ( Kim Dae-Su )
고려대학교 의과대학 병리학교실
최종상 ( Choi Jong-Sang )
고려대학교 의과대학 병리학교실
오화은 ( Oh Hwa-Eun )
관동대학교 의과대학 병리학교실
KMID : 0360320000320060989
Abstract
Purpose :Recent studies have demonstrated that angiogenesis and its inducers such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) play an important role in growth, progression, and metastasis in gastric carcinomas. In this study, the authors investigated the prognostic significance of angiogenesis, VEGF, bFGF with respect to conventional clinicopathologic factors in early gastric adenocarcinomas.
Materials and Methods :Sixty-six specimens resected from patients with early gastric carcinomas were investigated by immunohistochemical staining with antibodies against VEGF, bFGF, and CD31.
Results :In this study, high expression rates of VEGF and bFGF as well as high level of angiogenesis were observed. In addition, the expression rate of VEGF was correlated well with angiogenesis. However, the clinicopathologic factors, such as age, sex, location, growth pattern, lymph node metastasis, submucosal invasion, and degree of differentiation, were not significantly associated with the expression of VEGF and bFGF, and angiogenesis.
Conclusion :These results suggest that controlling angiogenesis and its inducers might be a therapeutic target rather than a prognostic factor in early gastric carcinomas.
키워드
Stomach neoplasm;Vascular endothelial growth factor;basic fibroblast growth factor;Angiogenesis;
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