GSTM1, GSTT1, L-myc Protooncogene의 유전자 다형성과 흡연, 음주, 식이요인에 따른 위암 발생의 위험도 평가
The Risk of Gastric Cancer in Koreans according to Smoking, Drinking, Diet, and the Genetic Polymorphisms of Glutathione S-Transferases and L-myc Protooncogene
대한암학회지 2000년 32권 6호 p.997 ~ 1006
박진우, 송영진, 윤효영, 김헌, 안윤옥, 김상준, 김진복, 강종원, 남홍매, 김용대,
소속 상세정보
박진우 ( Park Jin-Woo )
Chungbuk National University
송영진 ( Song Young-Jin )
Chungbuk National University
윤효영 ( Yun Hyo-Yung )
Chungbuk National University
김헌 ( Kim Heon )
Chungbuk National University
안윤옥 ( Ahn Yoon-Ok )
서울대학교 의과대학 예방의학교실
김상준 ( Kim Sang-Joon )
서울대학교 의과대학 외과학교실
김진복 ( Kim Jin-Pok )
인제대학교 의과대학 서울백병원 한국위암센터
강종원 ( Kang Jong-Won )
Chungbuk National University
남홍매 ( Nam Hong-Mei )
Chungbuk National University
김용대 ( Kim Yong-Dae )
Chungbuk National University
KMID : 0360320000320060997
Abstract
Purpose :This study was performed to investigate the interaction of genetic polymorphisms of glutathione S-transferases and L-myc proto-oncogene with smoking, drinking, and dietary factors in the carcinogenesis of gastric cancer.
Materials and Methods :Two hundred and four gastric cancer patients and 1：1 matched hospital controls were the study subjects. They were interviewed with a questionnaire including alcohol consumption, smoking and dietary habit. We investigated genetic polymorphisms of GSTM1, GSTT1 and L-myc genes using PCR-RFLP techniques.
Results :Smoking and soybean paste stew were risk factors and doughnut, fried potato, welsh onion, rice cake, seaweed, slices of raw fish, melon, tomato, garlic and onion were protective factors of gastric cancer. The odds ratios of some food items changed significantly according to the genotypes; green vegetables and pork according to the GSTM1 genotype; pork, soybean curd, steamed or hard-boiled soybean and welsh onion according to the GSTT1 genotype; rice cake and garlic according to the L-myc proto-oncogene genotype.
Conclusion :These results suggest that the genetic polymorphisms of GSTM1, GSTT1 and L-myc genes might modify the effects of environmental factors on gastric cancer possibly by engaging in the metabolism of food, alcohol and cigarette smoke.
키워드
Stomach neoplasm;Glutathione S-transferase mu;Glutathione S-transferase theta;L-myc gene;
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