장막 침범 위암 환자에서 수술 후 복강내 Cisplatin 투입의 치료 효과(후향적 연구)
Therapeutic Effect of the Intraperitoneal Cisplatin Installation (IPCI) in Advanced Gastric Carcinoma with Serosa Invasion Retrospective study
대한암학회지 2000년 32권 6호 p.1015 ~ 1021
김행수, 곽진호, 김용호, 이창환, 육정환, 오성태, 김병식, 박건춘,
소속 상세정보
김행수 ( Kim Haeng-Su )
울산대학교 의과대학 서울중앙병원 일반외과학교실
곽진호 ( Kwak Jin-Ho )
울산대학교 의과대학 서울중앙병원 일반외과학교실
김용호 ( Kim Yong-Ho )
울산대학교 의과대학 서울중앙병원 일반외과
이창환 ( Lee Chang-Hwan )
울산대학교 의과대학 서울중앙병원 일반외과학교실
육정환 ( Yook Jeong-Hwan )
울산대학교 의과대학 서울중앙병원 일반외과
오성태 ( Oh Sung-Tae )
울산대학교 의과대학 서울중앙병원 일반외과
김병식 ( Kim Byung-Sik )
울산대학교 의과대학 서울중앙병원 일반외과
박건춘 ( Park Kun-Choon )
울산대학교 의과대학 서울중앙병원 일반외과학교실
KMID : 0360320000320061015
Abstract
Purpose :We performed retrospective study to evaluate the preventive effect of intraperitoneal cisplatin installation (IPCI) on peritoneal recurrence after curative resection of advanced gastric cancer.
Materials and Methods :The effect of IPCI was evaluated in 297 advanced gastric carcinoma patients from January 1993 to December 1996. In IPCI group, 100 mg/body of cisplatin in one liter of saline was installed in peritoneal cavity before wound closure in operating room and drained out 2 hours later. Postoperative adjuvant chemotherapy with combination of 5-FU and cisplain was performed. 155 cases were treated by IPCI. Median follow-up period was 26 months.
Results :Out of 139 (46.8%) recurred cases, peritoneal, local and distant recurrences developed in 65 (37.8%) cases, 66 (38.4%) cases and 41 (23.8%) cases respectively. In univariated analysis for survival and recurrence, IPCI, T stage and N stage were significant prognostic factors. As regards to peritoneal recurrence, IPCI and T stage were significant factors. In multivariated survival analysis, as regards to recurrence, IPCI, T stage and N stage were significant prognostic factors. As regards to peritoneal recurrence, IPCI was the only significant independent prognostic factor.
Conclusion :We concluded that IPCI can effectively prevent peritoneal recurrence and overall recurrence and it shows marginal survival benefit in advanced gastric cancer patients with serosa invasion.
키워드
Stomach neoplasm;Intraperitoneal cisplatin installation;Peritoneal recurrence;
원문 및 링크아웃 정보
등재저널 정보