The Role of Expression of Vascular Endothelial Growth Factor (VEGF)-A and VEGF-C in Early Gastric Cancer
육정환, Ugoe Shoji-Nats, Ugoe Shoji-Nats, Che Xiangming, Sumiya Is higami, Kita Shuichi Ho, Baba Masamichi, Takao Sonshin, Aikou Takas-hi,
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육정환 ( Yook Jeong-Hwan )
울산대학교 의과대학 서울아산병원 외과학교실
( Ugoe Shoji-Nats )
울산대학교 의과대학 서울아산병원 외과학교실
( Ugoe Shoji-Nats )
Kagoshima University Depertment of Surgery
( Che Xiangming )
Kagoshima University Depertment of Surgery
( Sumiya Is higami )
Kagoshima University Depertment of Surgery
( Kita Shuichi Ho )
Kagoshima University Depertment of Surgery
( Baba Masamichi )
Kagoshima University Depertment of Surgery
( Takao Sonshin )
Kagoshima University Depertment of Surgery
( Aikou Takas-hi )
Kagoshima University Depertment of Surgery
KMID : 0360320010330020093
Abstract
Purpose :Tumor spread is mainly dependent on both hematogenous and lymphogeneous systems, and recently, several angiogenic factors have been identified. In the present study, we investigated whether the expressions of VEGF-A and -C are related with angiogenesis and lymph node metastasis in early gastric cancer.
Materials and Methods :A total of 97 specimens obtained from patients with early gastric cancer were studied by immunohistochemical methods using anti- VEGF-A and -C polyclonal antibodies, anti-Factor VIII- related antigen antibody, and anti-p53 antibody.
Results :The percentage of the positive expressions of VEGF-A and -C were 24.7% (24/97) and 25.7% (25/97), respectively. Significant differences were found between the expression of VEGF-A and lymphatic invasion and lymph node metastasis, and between expression of VEGF-C and gross type, lymphatic invasion, and lymph node metastasis (p＜0.05). The mean microvessel counts in VEGF-A and -C positive tumors were significantly higher than those in VEGF-A and -C negative tumors (p＜0.05). In multivariate analysis, tumor size, lymphatic invasion and VEGF-C were identified as independent factors related to lymph node metastasis (p＜0.05).
Conclusion :The expressions of VEGF-A and -C were found to be related to angiogenic activity and VEGF-C expression correlated significantly with lymph node metastasis. The determination of VEGF-C expression may be helpful for predicting lymph node metastases in early gastric cancer, and further studies involving many specimens are warranted.
키워드
Vascular endothelial growth factor;Angiogenesis;Lymph node metastasis;Early stomach neoplasm;
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