Prognostic Significance of Lymph Node Micrometastasis in pT2N0 Gastric Cancer
대한암학회지 2001년 33권 2호 p.130 ~ 135
이현국, 조삼제, 김윤호, 이혜승, 김우호, 이건욱, 최국진, Km Jin-Pok, 양한광,
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이현국 ( Lee Hyeon-Kook )
서울대학교 의과대학 외과학교실
조삼제 ( Cho Sam-Je )
서울대학교 의과대학 외과학교실
김윤호 ( Kim Yoon-Ho )
서울대학교 의과대학 외과학교실
이혜승 ( Lee Hye-Seung )
서울대학교 의과대학 병리학교실
김우호 ( Kim Woo-Ho )
서울대학교 의과대학 병리학교실
이건욱 ( Lee Kuhn-Uk )
서울대학교 의과대학 외과학교실
최국진 ( Choi Kook-Jin )
서울대학교 의과대학 외과학교실
( Km Jin-Pok )
서울대학교 의과대학 외과학교실
양한광 ( Yang Han-Kwang )
서울대학교 의과대학 외과학교실
KMID : 0360320010330020130
Abstract
Purpose :The prognostic significance of lymph node (LN) micrometastasis in gastric cancer remains controversial. We therefore investigated the clinicopathologic factors related to LN micrometastasis and evaluated the clinical relevance of micrometastasis with regard to recurrence.
Materials and Methods :A total of 1083 LNs from 39 patients with pT2N0 gastric cancer and who underwent curative resection in 1993 were further immunohistochemically stained using an anti-cytokeratin Ab cocktail (AE1-AE3).
Results :Micrometastases were found in 3.9% (42/1083) of the resected LNs and 53.8% (21/39) of the patients with pT2N0 gastric cancer. LN micrometastasis was found to be significantly related with histologic differentiation. The recurrence rate of gastric cancer was higher in patients with LN micrometastasis (31.6%) than in those without (6.3%), with a borderline significance (p=0.074). In univariate analysis, patients with LN micrometastasis had a shorter 5-year disease-free survival (65%) than those without LN micrometastasis (87%) (p=0.075). In multivariate analysis, multiple LN micrometastasis was associated with a poor prognosis, but with a borderline significance (p=0.069, Risk ratio 4.815)
Conclusion :We were able to identify LN micrometastases missed on routine H-E staining, using an immuno histochemical technique. Our results suggest that LN micrometastasis is associated with the recurrence of pT2N0 gastric cancer.
키워드
Stomach neoplasm;Micrometastasis;
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