A Clinicopathological Analysis of Recurrent Gastric Cancer
대한암학회지 2001년 33권 3호 p.207 ~ 215
양한광, 조삼제, 정기욱, 김윤호, 이현국, 이건욱, 최국진, 김진복,
소속 상세정보
양한광 ( Yang Han-Kwang )
서울대학교 의과대학 외과학교실
조삼제 ( Cho Sam-Je )
서울대학교 의과대학 외과학교실
정기욱 ( Chung Ki-Wook )
서울대학교 의과대학 외과학교실
김윤호 ( Kim Yoon-Ho )
서울대학교 의과대학 외과학교실
이현국 ( Lee Hyeon-Kook )
서울대학교 의과대학 외과학교실
이건욱 ( Lee Kuhn-Uk )
서울대학교 의과대학 외과학교실
최국진 ( Choi Kook-Jin )
서울대학교 의과대학 외과학교실
김진복 ( Kim Jin-Pok )
인제대학교 의과대학 서울백병원 한국위암센터
KMID : 0360320010330030207
Abstract
Purpose :This study was designed to investigate the correlation between the clinicopathologic characteristics and the recurrence pattern of gastric cancer and to define survival difference according to treatment modality after diagnosis of recurrence.
Materials and Methods :We retrospectively reviewed the medical records of 4184 patients who had undergone radical surgery for primary gastric cancer from 1986 through 1996. Clinicopathologic factors were analyzed for the relationship of each factor with the pattern of recurrence. And the survival after diagnosis of recurrence was compared among the treatment modalities.
Results :Recurrence pattern was confirmed in 1141 patients. Loco-regional recurrence occurred in 291 patients (20.1%), peritoneal recurrence in 383 (26.5%), distant recurrence in 290 (20.1%), and mixed recurrence in 177 (12.3%), respectively. Early recurrence (less than 2 years) occurred in 767 (69.3%), intermediate recurrence(2∼5 years) in 286 (25.8%), and late recurrence (more than 5 years) in 54 (4.9%). In multivariate analysis, T stage, N stage, size of tumor and perineural invasion were independent prognostic factors for recurrence. Median survival from diagnosis of recurrence was 24.2 months in the curative operation group, 7.7 months in the chemotherapy group, 7.1 months in the non-curative
operation group and 3.3 months in the conservative treatment group, respectively (p=0.000).
Conclusion :The clinicopathological analysis of recurrent gastric cancer showed recurrent patterns and prognostic factors. Curative resection is suggested to have survival benefit in recurrent gastric cancer patients, although it was possible in patients with limited extent of disease.
키워드
Stomach neoplasm;Recurrence;Recurrence pattern;Survival;
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