Expression of Cyclooxygenase - 2 in Human Breast Carcinoma : Relevance to Tumor Angiogenesis and Expression of Estrogen Receptor
대한암학회지 2001년 33권 4호 p.286 ~ 295
소속 상세정보
강행지/Haeng Ji Kang
공구/장세진/정파종/박찬금/Gu Kong/Se Jin Jang/Pa Jong Jung/Chan Kum Park
KMID : 0360320010330040286
Abstract
PURPOSE: This study investigates the COX-2 expression in human primary breast carcinomas and its relationship with both angiogenesis and the expression of estrogen receptor.
MATERIALS AND METHODS: COX-2 expression, angiogenesis, and estrogen receptor expression were examined by immunohistochemical methods in 167 human breast carcinomas by using monoclonal antibodies against COX-2, CD34, and estrogen receptor protein.
RESULTS: Although COX-2 was expressed in 77.8% of the breast carcinomas (130/167) regardless of histological types, it was not detected at all in benign epithelial cells. Interestingly, COX-2 expression was found to be significantly correlated with tumor angiogenesis (p=0.004), but not with estrogen receptor and other histopathologic parameters.
CONCLUSION: The results suggest that COX-2 expression occurs frequently in breast tissue during transformation of benign epithelial cells to malignant cells regardless of the estrogen receptor status. COX-2 expression may play a role in tumor angiogenesis that is responsible for tumor growth and metastasis.
키워드
Breast neoplasm; Cyclooxygenase-2; Angiogenesis; Estrogen receptor;
원문 및 링크아웃 정보
등재저널 정보