Expressions of Multidrug Resistance - Related Genes in Gastric Cancer Tissue and Normal gastric Mucosal Tissue
대한암학회지 2001년 33권 4호 p.302 ~ 308
송석훈, 김상운, 송선교, 최준혁, 하정희, 이경희,
소속 상세정보
송석훈 ( Song Seok-Hun )
영남대학교 의과대학 응급의학과
김상운 ( Kim Sang-Woon )
영남대학교 의과대학 외과학교실
송선교 ( Song Sun-Kyo )
영남대학교 의과대학 외과학교실
최준혁 ( Choi Joon-Hyuk )
영남대학교 의과대학 병리학교실
하정희 ( Ha Jeoung-Hee )
영남대학교 의과대학 약리학교실
이경희 ( Lee Kyoung-Hee )
영남대학교 의과대학 내과학교실
KMID : 0360320010330040302
Abstract
Purpose: This study was conducted to evaluate the expressions of the mdr1 gene and the MRP gene in tumor and adjacent normal gastric tissues.
Materials and Methods: The specimens were obtained from 53 patients who had gastric cancer. None of these patients had received any kind of preoperative chemo-therapy. The reverse transcription polymerase chain reaction and immunohistochemical stain were used to check the level of expressions of mRNAs and their associated proteins .
Results: Highly positive expressions of mdr1 mRNA, MRP mRNA, p-glycoprotein, and MRP (multidrug resistance associated protein) were observed in the tumor and the adjacent normal tissues. Most tumor tissues coex-pressed mdr1 mRNA and MRP mRNA significantly (p ＜0.001). The expression of these genes in the tumor was muchstronger than in the normal counterpart tissues. The expression of the p-glycoprote in was correlated only with the pathological stage (p＜0.05). MRP expression was correlated with lymph node metastas is (p＜0.05).
Conclusion: Normal gastric tissue showed strong physiologic expressions of the mdr1 and MRP genes. Overexpressions of these genes were observed in gastric cancer tissue. The presence of multidrug resistances hould be considered when planning anticancer che-motherapy for treating gastric cancer.
키워드
Stomach neoplasm;Multidrug resistance;p-glycoprotein;Multidrug resistance associated protein;
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