Genetic Alterations in Gastric Carcinomas and Adjacent Mucosa Detected by Comparative genomic Hybridization ( CGH )
대한암학회지 2001년 33권 4호 p.309 ~ 317
김동완, 최석진, 이지영, 김규종, 박무인, 박선자, 구선회, 구자영,
소속 상세정보
김동완 ( Kim Dong-Wan )
고신대학교 의과대학 내과학교실
최석진 ( Choi Seok-Jin )
고신대학교 의과대학 내과학교실
이지영 ( Lee Jee-Young )
고신대학교 의과대학 내과학교실
김규종 ( Kim Kyu-Jong )
고신대학교 의과대학 내과학교실
박무인 ( Park Moo-In )
고신대학교 의과대학 내과학교실
박선자 ( Park Seun-Ja )
고신대학교 의과대학 내과학교실
구선회 ( Koo Sun-Hoe )
충남대학교 의과대학 임상병리학교실
구자영 ( Koo Ja-Young )
고신대학교 의과대학 내과학교실
KMID : 0360320010330040309
Abstract
Purpose: Comparative genomic hybridization (CGH) was used to detectany amplified ordeleted chromosomal
regions in tumors by mapping their locations on normal metaphase chromosomes.
Materials and Methods: Twenty-six gastric carcinomas and their adjacent mucosa were screened for chro-mosomal aberrations using CGH.
Results: All carcinomas had chromosomal aberrations, and chromosomal material was more likely to be gained
than lost. Ten out of 26 adjacent mucosa had chromoso mal aberrations, and again was less frequently observed than a tumor (1.6/2.6). The most common gains were detected on 13q (58.3%), 8q (30.8%), 6q (27.0%), and 20p (19.2%), while the most freque nt losses were de-tected on 17p (38.5%) and 16q (7.2%). The most common chromosomal aberrations in the adjacent mucos a were a gain of 13q (11.5%) and a loss of 17q (11.5%). The tumors had more chromosomalgains of 2q, 3q, and 13q and more losses of 17p and 16q than the adjacent mucosa.
Conclusion: The most common gain in the tumors was detected on 13q, 8q, 6q, and 20p, and the most frequent loss was on 17p and 16q. While CGH may be useful in predicting the prognos is ortherapeutic decision of gastric carcinomas, furthers tudy of several candidate genes, such as DP1, FLT1, c-myb, AIB1, BTAK, is needed to clarify gastric carcinogenes is and its progression.
키워드
Stomach neoplasm;Gene alterations;Comparative genomic hybridization;
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