Surface characterization of 2-hydroxypyrimidine sulphate by inverse gas chromatography
Praveen Kumar B., Madhusudana Reddy T., Reddy K. S.,
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( Praveen Kumar B. )
Sri Venkateswara University Department of Chemistry
( Madhusudana Reddy T. )
Sri Venkateswara University Department of Chemistry
( Reddy K. S. )
Sri Venkateswara University Department of Chemistry
Abstract
The net retention volumes, VN, of n-alkanes and polar probes on 2-hydroxypyrimidine sulphate (2-HPS) drug surface are determined at 323.15, 328.15 and 333.15 K using inverse gas chromatography. The dispersive surface free energy, ¥ãdS¥ãSd of 2-HPS are evaluated by applying Schultz method as well as Dorris?Gray method and found that ¥ãdS¥ãSd values are higher by 8 per cent in the latter method. The ¥ãdS¥ãSd values are decreasing in both the methods with increase of temperature. The specific component of the free energy of adsorption, ¥ÄGSa¥ÄGaS , for polar probes are obtained by three methods proposed by Schultz et al., Saint Flour?Papirer and Sawyer?Brookman. The Lewis acid?base parameters, Ka and Kb, are calculated using ¥ÄGSa¥ÄGaS values. The surface character value, S = (Kb/Ka) according to the Schultz et al., is found to be 3.9 whereas the S value in the other two methods are found to be 6.2 and 5.6. The results demonstrate that the 2-HPS powder surface contain relatively more basic sites and can interact strongly in the acidic media.
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Inverse gas chromatography (IGC); 2-Hydroxypyrimidine sulphate (2-HPS); Dispersive surface free energy; Lewis acid?base parameters
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