임신성 유방암(Pregnancy Associated Breast Cancer PABC) 8예에 대한 임상분석
Clinical Analysis of 8 Cases of Pregnancy Associated Breast Cancer
이해경,
소속 상세정보
이해경 ( Lee Hae-Kyung )
성균관대학교 의과대학 삼성제일병원 일반외과
KMID : 0371320010600010041
Abstract
Purpose: Although breast cancer is the most common malignancy diagnosed during pregnancy, it is a comparatively rare finding during pregnancy or lactation with a reported occurrence of approximately 1 out of 3,000 pregnancies. The diagnosis of pregnancy-associated breast cancer (PABC) remains challenging because of the associated anatomical and physiologic changes in the breast, and the treatment of PABC is complicated by potential fetal injury secondary to both radiation therapy and chemotherapy. We will describe eight cases of PABC, review special considerations of unique diagnostic and therapeutic modalities, and discuss childbearing-related issues in survivors.
Methods: The medical records of 8 patients with PABC who had been treated between August 1988 and May 2000 at the Department of Surgery, Samsung Cheil Hospital were retrospectively reviewed for clinical, radiological, and pathological findings, treatment modalities, and follow-up results.
Results: The incidence of PABC was about 0.01% (8 cases of PABC/71,401 pregnancies). One of eight died from carcinomatosis at 47 months after diagnosis, and the remaining 7 patients are free of disease. Two women terminated pregnancy at 28 weeks, one of which had twins. The remaining 6 babies were live births and healthy, two of whom were exposed in utero to cancer chemotherapy.
Conclusion: The delayed diagnosis of PABC and the coexistence of pregnancy makes the management of PABC difficult, but a comprehensive, multidisciplinary approach to the management of PABC can allow the continuation of pregnancy.
키워드
유방암;임신;치료
Breast cancer;Pregnancy;Management
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