췌장 선방세포암의 임상적 고찰 -본원 5예와 국내 증례 보고된 5예를 중심으로-
Clinical Study of Acinar Cell Carcinomas of the Pancreas -Our 5 cases and a review of 5 cases reported in Korea-
김민찬, 정갑중, 김형호, 김상순,
소속 상세정보
김민찬 ( Kim Min-Chan )
동아대학교 의과대학 외과학교실
정갑중 ( Jung Ghap-Joong )
동아대학교 의과대학 외과학교실
김형호 ( Kim Hyung-Ho )
동아대학교 의과대학 외과학교실
김상순 ( Kim Sang-Sun )
동아대학교 의과대학 외과학교실
KMID : 0371320010600010097
Abstract
Purpose: A acinar cell carcinoma of the pancreas is a rare malignancy arising from exocrine cells and comprising about 0.2 to 1% of all pancreatic cancers. Acinar cell carcinomas are usually seen in elderly patients and show a poor prognosis due to frequent metastasis. So far, we have not found any report of a clinical analysis of acinar cell carcinomas in Korean.
Methods: The records of 5 patients of Dong-A University Hospital and 5 patients already reported on in other literature in Korea were reviewed. The clinical and radiohistologic characteristics, treatment and prognosis were analyzed.
Results: The patients consisted of 8 males and 2 female. The patients ranged in age from 25 to 68 years (mean, 49.3 years). Presenting symptoms were nonspecific, and jaundice was infrequent. The symptoms from increased serum lipase levels were present in 2 (20.0%) of the patients. The tumor was frequen tly located on the tail (6 cases, 60.0%) of the pancreas. The histologic finding showed an acinar arrangement of the tumor cells with a minute central lumen. Ultrastructurely, the tumor cells had a few zymogen granules. The mean size of the tumors was 7.5 cm. We found that 1 case among the 10 cases had an elevated CA19-9 level among 10 cases and no one had an elevated AFP or CEA level among our 5 cases. A radical resection was performed in 7 cases, and the mean survival was 44.0 months. The
mean survival of the 10 cases was 35.4 months.
Conclusion: An acinar cell carcinoma is a rare type of pan creatic cancer and has a more favorable prognosis than a pancreatic ductal carcinoma. The clinical outcome and the radiohistologic characteristics were similar to those in other foreign literature, but the age, the tumor locations and the tumor marker (AFP or CEA) of the patients in this study were different from those of Caucasians.
키워드
선방 세포암; 췌장
Acinar cell carcinoma; Pancreas
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