유방암에서 HMGI(Y) 유전자 발현 및 병리 조직학적 관계에 대한 연구
The Expression of High Mobility Group I (Y) Proteins in Human Breast Cancer
류진우,
소속 상세정보
류진우 ( Ryu Jin-Woo )
단국대학교 의과대학 외과학교실
KMID : 0371320010600020136
Abstract
Purpose: The precise mechanisms of tumorigenesis of breast cancer remains unknown in spite of major efforts. Recent studies have shown that High Mobility Group I (Y) Proteins [HMGI(Y)] have an important role in the regulation of chromatin structure and function, and that HMGI(Y) protein expression is generally correlated with a malignant phenotype. This study was undertaken to define the relationship of the HMGI(Y) protein expression between malignant breast tissue and non-malignant breast tissue in human, and clinico- pathologic findings were reviewed for this purpose.
Methods: Using Reverse Transcription-Polymerase Chain Reaction (RT-PCR) for HMGI(Y) with β-actin, this study demonstrated the expression of HMGI(Y). The p53, ER, and PR. were defined by immunohistochemical staining.
Results: The HMGI(Y) expression was increased in the malignant tissue (90%), than in benign (76.9%) or normal (65%) tissue (p=0.031). As for the invasive ductal cancers, there was no difference between the HMGI(Y) expression and histopathologic parameters.
Conclusion: These results suggest that the HMGI(Y) expression may be of little pathogenetic prognostic importance in human breast cancer.
키워드
HMGI(Y);유방암
HMGI(Y);Breast cancer
원문 및 링크아웃 정보
등재저널 정보