생체염료의 유방실질내 및 유륜하 동시 주입법에 의한 감시 림프절 생검성적 향상
Combined Peritumoral and Subareolar Injection of Blue Dye Improves Sentinel Lymph Node Localization Rates
윤석현, 박혜덕, 김제룡, 장일성,
소속 상세정보
윤석현 ( Yoon Seok-Hyun )
충남대학교 의과대학 일반외과학교실
박혜덕 ( Park Hye-Duck )
충남대학교 의과대학 일반외과학교실
김제룡 ( Kim Je-Ryong )
충남대학교 의과대학 일반외과학교실
장일성 ( Chang Eil-Sung )
충남대학교 의과대학 일반외과학교실
KMID : 0371320010600020148
Abstract
Purpose: The sentinel lymph node (SLN) biopsy was recently introduced into the treatment of early breast cancer. However, there have been varying degrees of success in identifying the SLNs. Lymphatic mapping in breast cancer performed solely by intraparenchymal injection of blue dye remains an accepted method of identifying SLNs, largely because of its simplicity. This article describes the technical aspect and improved results of combined peritumoral and subareolar injection of isosulfan blue dye.
Methods: From Jan. 2000 to Jul. 2000, 55 patients with breast cancer (size＜5 cm and clinically negative axillary nodes) were enrolled for SLN biopsy by peritumoral and subareolar injection of 1% isosulfan blue dye. And all patients underwent a complete axillary dissection.
Results: The identification rate of SLN was 96.4% (in 53 of 55 patients). Of these 53 patients, 11 patients (20.8%) had positive SLNs and 42 patients had negative SLNs. In 42 patients with negative SLNs, one patients was found to have disease on complete dissection, for a false-negative rate of 8.3% (1/12).
Conclusion: Compared with other series of blue dye- directed lymphatic mapping, the present study of peritumoral plus subareolar plexus dye-only injection demonstrates a high SLNs localization rate and rapid learning curve. On the basis of these results, it is expected that subareolar lymphatic plexus is the central route to sentinel lymph nodes and the optimal way to perform dye-only lymphatic mapping of the breast.
키워드
유방암;감시 림프절 생검;생체염료
Breast cancer;Sentinel lymph node biopsy;Blue dye
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