Gynecomastia 조직에서 면역화학염색법에 의한 Estrogen Receptor α, β와 Progesterone Receptor의 발현
Estrogen Receptor α, β and Progesteron Receptor Expression in Gynecomastia Using Immunohistochemical Staining
박순철, 김기환, 김정수, 안창혁, 전해명, 이은정, 정상설,
소속 상세정보
박순철 ( Park Sun-Cheol )
가톨릭대학교 의과대학 의정부성모병원 외과학교실
김기환 ( Kim Kee-Hwan )
가톨릭대학교 의과대학 의정부성모병원 외과학교실
김정수 ( Kim Jeong-Soo )
가톨릭대학교 의과대학 의정부성모병원 외과학교실
안창혁 ( An Chang-Hyeok )
가톨릭대학교 의과대학 의정부성모병원 외과학교실
전해명 ( Jeon Hae-Myung )
가톨릭대학교 의과대학 의정부성모병원 외과학교실
이은정 ( Lee Eun-Jung )
가톨릭대학교 의과대학 의정부성모병원 임상병리학교실
정상설 ( Jung Sang-Seol )
가톨릭대학교 의과대학 의정부성모병원 외과학교실
KMID : 0371320010600030268
Abstract
Purpose: Gynecomastia is a common male breast abnormality and primarily occurs in puberty and senescence. The obvious etiological role of hormonal changes in gynecomastia, plus the discovery of estrogen receptor in normal and neoplastic breast, has spurred several investigations of ER content in male gynecomastic tissues. The results have been inconsistent and the fraction of ER-positive specimens has varied from 0∼90%.
Methods: Immunohistochemical hormonal receptor analysis using monoclonal estrogen receptor (ER) α, β and progesteron receptor (PR) was performed on the breast tissues of 58 patients with gynecomastia bet
ween January 1995 and January 2000 in the Department of Surgery, Uijongbu St. Mary’s Hospital. These results were statistically compared with clinical data.
Results: 48 cases (82.8%) were ERα positive and 55 cases (94.8%) were ERβ positive and PR positivity was noted in 55 cases (94.8%). There was negative relationship between ERα and age, PR and location.
Conclusion: This study demonstrates that intracellular steroid receptors are present in most gynecomastic tissues. Additionally, it supports the general assumption that estrogen and progesteron may be two of the hormones responsible for the development of gynecomastia.
키워드
여성형 유방;에스트로젠 수용체 알파;베타;프로제스테론 수용체
Gynecomastia;Estrogen receptor α;β;Progesteron receptor;
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