간절제술 전후의 혈청 Interleukin-6의 변화와 간기능과의 관계
Changes of Serum Interleukin-6 after Liver Warm Ischemia/Reperfusion Injury and Postoperative Liver Function Improvement
박영만, 윤명희, 신동훈, 이충한, 박영훈,
소속 상세정보
박영만 ( Park Young-Man )
고신대학교 복음병원 일반외과
윤명희 ( Yoon Myung-Hee )
고신대학교 복음병원 일반외과
신동훈 ( Shin Dong-Hoon )
고신대학교 복음병원 일반외과
이충한 ( Lee Chung-Han )
고신대학교 복음병원 일반외과
박영훈 ( Park Young-Hoon )
고신대학교 복음병원 일반외과
KMID : 0371320010600030320
Abstract
Purpose: Although the liver is an important source of IL-6 and the primary site for its clearance, the role of IL-6 in liver disease remains unclear. Warm ischemia/reperfusion (WI/Rp) injury to the liver occurs in numerous clinical situations including liver transplantation and surgery, trauma, hemorrhagic and endotoxic shocks, and thermal injury. A better understanding of the pathogenesis of WI/Rp injury of the liver and the availability of an agent that could alleviate Rp injury would have important clinical implications. The aim of this study was to evaluate the role of IL-6 in WI/Rp injury of the liver.
Methods: Thirteen patients who had undergone hepatectomy were evaluated with regard to postoperative changes in serum IL-6. The measurements were performed before surgery, within 30 minutes after WI/Rp injury, and at postoperative 24 hr, 48 hr, 1 wk, 2 wk, and 4 wk. Seven of 13 patients had the complication of cirrhosis.
Results: The mean value of IL-6 was 8.13 pg/ml preoperatively, and peaked at 20.51 pg/ml on the first postoperative day. Serum IL-6 levels within 30 minutes following WI/Rp injury and at postoeprative 1 day were higher in patients with cirrhosis than non-cirrhotic patients, although statistically insignificant. In the case of the cirrhotic patients, IL-6 values on the first postoperative day peaked at 40.81 pg/ml, compared to 35.27 pg/ml in non-cirrhotic patients. SGOT and SGPT were consistently increased with IL-6 on the first postoperative day, and gradually decreased thereafter.
Conclusion: This study shows that IL-6 may be an indicator in WI/Rp injury of the liver. Procedures undertaken to reduce the excessive production of this cytokine may be useful of improving postoperative liver function with or without cirrhosis.
키워드
간의 허혈 및 재관류 손상;인터루킨-6
Warm Ischemia/Reperfusion injury;Interleukin-6
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