원발성 유방암에서 Cathepsin D의 발현과 예후인자와의 상관성
Relationship between Cathepsin D Expression and Other Prognostic Factors in Primary Breast Cancer
정우진, 이광만, 윤기중, 박동은, 채권묵,
소속 상세정보
정우진 ( Chung Woo-Jin )
원광대학교 의과대학 외과학교실
이광만 ( Lee Kwang-Man )
원광대학교 의과대학 외과학교실
윤기중 ( Yun Ki-Jung )
원광대학교 의과대학 병리학교실
박동은 ( Park Dong-Eun )
원광대학교 의과대학 외과학교실
채권묵 ( Chae Kwon-Mook )
원광대학교 의과대학 외과학교실
KMID : 0371320010600040368
Abstract
Purpose: Cathepsin D, a lysosomal protease has been proposed to play a role in the local invasion and metastatic dissemination in primary breast cancer. Although there are many conflicting results, the overexpression of cathepsin D has been considered to be related with a poorer prognosis of breast cancer. This study was designed to verify whether cathepsin D expression is related to other prognostic factors in breast cancer.
Methods: Cathepsin D was assessed by immunohistochemistry using murine monoclonal anti-cathepsin D antibody (ZyMED) in 79 paraffin-embedded primary breast cancer specimens. Cathepsin D expression was compared to other prognostic parameters such as tumor size, axillary lymph node metastasis, tumor histologic grades, hormone re
ceptors (ER & PR), p53, c-erb B2, Ki-67, MVD (microvessel density), and Pgp (P-glycoprotein).
Results: A high-expression of cathepsin D was found in 35 of 79 patients (44.3%) with primary breast cancer. Cathepsin D expression was not related to tumor size, axillary lymph node metastasis, tumor histologic grades, hormone receptors, p53, Ki-67, or CD31. However, a significant relationship was found between cathepsin D expression and c-erb B2 (p=0.007), and between cathepsin D expression and Pgp (p=0.003).
Conclusion: These results suggest that cathepsin D expression may be an indicator of a poor prognosis in breast cancer. However, further studies are required to verify the exact role of cathepsin D in the prognosis of breast cancer.
키워드
Cathepsin D;유방암 예후인자
Cathepsin D;Prognostic factors in breast cancer
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