임신과 관련된 유방암
Pregnancy-Associated Breast Cancer
강세훈, 오승근, 최국진, 윤여규, 노동영, 김성원, 강희준,
소속 상세정보
강세훈 ( Kang Se-Hoon )
서울대학교 의과대학 외과학교실
오승근 ( Oh Seung-Keun )
서울대학교 의과대학 외과학교실
최국진 ( Choi Kook-Jin )
서울대학교 의과대학 외과학교실
윤여규 ( Youn Yeo-Kyu )
서울대학교 의과대학 외과학교실
노동영 ( Roh Dong-Young )
서울대학교 의과대학 외과학교실
김성원 ( Kim Sung-Won )
서울대학교 의과대학 외과학교실
강희준 ( Kang Hee-Joon )
서울대학교 의과대학 외과학교실
KMID : 0371320010600040380
Abstract
Purpose: Women pregnant or lactating at the time of breast cancer diagnosis exhibit a significantly more advanced stage disease at the time of diagnosis than non-pregnant women. The goal of this study was to identify pregnancy-associated breast cancer, and to compare the clinicopathologic characteristics and disease-free survival rates with those of non- pregnancy associated breast cancer.
Methods: The medical records of women pregnant or within 1 year postpartum at the time of breast cancer diagnosis and those of non-pregnant women with breast cancer between 1981 and 1999, were analyzed. Fourteen women with pregnancy-associated breast cancer (group I) were compared to 155 non-pregnant women with breast cancer (group II) of comparable ages, and to 1201 women with breast cancer age of 36 or older (group III).
Results: No significant differences were found in regards to dominant histologic types, hormone receptor statuses or histologic grade among those three groups. The delay in diagnosis of group I averaged 5.2 months longer than that of group II (P＜0.001). Group I was found to have larger (≥5 cm) tumors, and a greater portion had advanced staged (stage≥III) cancer than group II (P＜0.025). Stage by stage, there was no significant statistical difference in disease-free survival rates between group I and group II. The younger patients (group I, group II) had lower disease-free survival rates than older patients (group III) (P＜0.05).
Conclusion: No specific pathologic characteristics were found in pregnancy associated breast cancer. The delay in diagnosis and young age at diagnosis may be the primary reasons for the relatively advanced stages seen in breast cancer associated with pregnancy.
키워드
유방암;임신;예후
Breast cancer;Pregnancy;Prognosis
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