갑상선 종양에서의 p27kip1의 발현
Expression of p27kip1 in the Thyroid Neoplasms
유종원, 차성재, 박성준, 박성일, 이태진, 임현묵,
소속 상세정보
유종원 ( Yoo Jong-Won )
중앙대학교 의과대학 외과학교실
차성재 ( Cha Sung-Jae )
중앙대학교 의과대학 외과학교실
박성준 ( Park Sung-Jun )
중앙대학교 의과대학 외과학교실
박성일 ( Park Sung-Il )
중앙대학교 의과대학 외과학교실
이태진 ( Lee Tae-Jin )
중앙대학교 의과대학 병리학교실
임현묵 ( Lim Hyun-Muk )
중앙대학교 의과대학 외과학교실
KMID : 0371320010600040386
Abstract
Purpose: Cyclin-dependent kinase inhibitor, p27kip1 is an important cell-cycle regulator. In recent studies, the loss of p27kip1 expression has been examined in many neoplasms including colorectal cancer and breast cancer. The aims of this study are to evaluate the correlation between p27 expression and carcinogenesis of the thyroid gland and to determine its clinical applications.
Methods: Immunohistochemical staining for p27kip1 was performed in 10 nodular goiters, 12 follicular adenomas, 8 minimally invasive follicular carcinomas, 6 widely invasive follicular carcin
omas, and 26 papillary carcinomas.
Results: p27kip1 was expressed in 90.0% (9/10) of nodular goiters, 66.7% (8/12) of follicular adenomas, 62.5% (5/8) of minimally invasive follicular carcinomas, 33.3% (2/6) of widely invasive follicular carcinomas, and 46.2% (12/26) of papillary carcinomas (P＞0.05). The expression of p27kip1 was not found to be correlated with tumor size in either neoplasms or nodal metastasis in papillary carcinoma.
Conclusion: These results suggest that p27kip1 does play some role in the tumorigenesis of thyroid cancer but is not a prognostic factor.
키워드
p27kip1;갑상선 종양
p27kip1;Thyroid neoplasm
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