유방암조직에서 당 수송단백 GLUT1의 발현 양상과 유방암 예후 인자와의 상관관계
Expression Pattern of Glucose Transporter GLUT1 Protein & Its Correlation with Prognostic Factors in Breast Cancer
김병진, 노미숙, 정갑중, 조세헌, 홍숙희, 김상순,
소속 상세정보
김병진 ( Kim Byung-Jin )
동아대학교 의과대학 외과학교실
노미숙 ( Roh Mee-Sook )
동아대학교 의과대학 병리학교실
정갑중 ( Jung Ghap-Joong )
동아대학교 의과대학 외과학교실
조세헌 ( Joh Se-Heon )
동아대학교 의과대학 외과학교실
홍숙희 ( Hong Sook-Hee )
동아대학교 의과대학 병리학교실
김상순 ( Kim Sang-Sun )
동아대학교 의과대학 외과학교실
KMID : 0371320010600050477
Abstract
Purpose: Breast cancer of malignant tumor occurring in domestic women is a tumor frequently seen in the third order following uterine cervical cancer and gastric cancer. This tumor may be recur even following positive treatment, so various
methods: have been studied to elucidate risk factors for recurrence. In particular, among the various oncogenes concerned in the recurrence of breast cancer, some have been seen as prognostic factors. In a recent study of protein expression in the tumor cell, it was demonstrated that expression increases glucose uptake and utilization, and that Glut1 facilitating the glucose transporter is increased in expression in various tumors of body. Many studies have been conducted on the role of protein in this glucose transporter in breast cancer, yet more studies are required.
Methods: Dye studies were carried out according to an ordinary ABC method utilizing polyclonal anti-Glut1 antibody to detect Glut1 protein in 79 breast cancer samples.
Results: Among the 79 breast cancer tissue samples, 41 samples (52%) demonstrated expression of Glut1. Upon close examnination, the expression frequency of Glut1 in brest cancer in relation to existing breast cancer prognosis- related factors, showed a statistically significant correlation with the histologic grade of the breast cancer.
Conclusion: As Glut1 positive expression was seen in the breast cancer cell, it is suggested that Glut1 is involved in the occurrence of breast cancer. In particular, in poorly differentiated breast cancer, the expression was frequencyincreased, which suggested its potential as a prognostic factor for breast cancer.
키워드
유방암;Glut1
Breast cancer;Glut1
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