대장직장암에서 p27Kip1 단백 발현과 임상병리학적 예후인자와의 관계
Expression of p27Kip1 Protein and Correlation with Clinicopathologic Factors in Colorectal Carcinoma
홍범기, 장인택, 박성일, 이태진, 지경천, 이정효, 박용검, 김형중,
소속 상세정보
홍범기 ( Hong Bum-Ki )
중앙대학교 의과대학 외과학교실
장인택 ( Chang In-Taek )
중앙대학교 의과대학 외과학교실
박성일 ( Park Sung-Il )
중앙대학교 의과대학 외과학교실
이태진 ( Lee Tae-Jin )
중앙대학교 의과대학 병리학교실
지경천 ( Chi Kyong-Chon )
중앙대학교 의과대학 외과학교실
이정효 ( Lee Jung-Hyo )
중앙대학교 의과대학 외과학교실
박용검 ( Park Yong-Gum )
중앙대학교 의과대학 외과학교실
김형중 ( Kim Hyung-Jung )
중앙대학교 의과대학 병리학교실
KMID : 0371320010600050536
Abstract
Purpose: The p27Kip1 gene has been recognized as a negative regulator of the cell cycle and a potential tumor suppressor gene. Reduced expression of the p27Kip1 protein has been reported in several human tumors and has been associated with a poor prognosis in breast, lung, colon, prostate, bladder, esophageal and gastric cancers. In the present study, we assessed p27 expression in patients with colorectal cancer in relation to their clinicohistological parameters.
Methods: We investigated p27 expression in 80 patients with colorectal cancers using immunohistochemical staining and the results were analyzed regarding the survival and clinicopathological parameters.
Results: Among 80 cases of clolorectal carcinomas, p27Kip1 expression was detected in the nuclei of tumor cells in 48 cases (60%). With the exception of differentiation (p＜0.01), no significant correlation was found between p27Kip1 and TMN stage, lymph node metastasis, depth of tumor invasion or overall survival.
Conclusion: The results suggest that reduced expression of p27Kip1 protein plays a role in the differentiation of colorectal carcinoma and may be a potential prognostic factor. But, more studies are reqired in order to determine whether p27Kip1 protein expression is a clinically valuable prognostic factor.
키워드
대장직장암종;P27Kip1
Colorectal carcinoma;P27Kip1
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