담낭암세포에서의 p53, c-erbB-2 및 Ki-67 단백질 발현의 임상적 유용성
The Clinical Value of p53, c-erbB-2 and Ki- 67 Expression in Gallbladder Carcinoma
김기환, 최성호, 안창혁, 김정수, 전해명, 이은정, 임근우,
소속 상세정보
김기환 ( Kim Kee-Hwan )
가톨릭대학교 의과대학 의정부성모병원 외과학교실
최성호 ( Choi Seong-Ho )
가톨릭대학교 의과대학 의정부성모병원 외과학교실
안창혁 ( An Chang-Hyeok )
가톨릭대학교 의과대학 의정부성모병원 외과학교실
김정수 ( Kim Jeong-Soo )
가톨릭대학교 의과대학 의정부성모병원 외과학교실
전해명 ( Jeon Hae-Myung )
가톨릭대학교 의과대학 의정부성모병원 외과학교실
이은정 ( Lee Eun-Jung )
가톨릭대학교 의과대학 의정부성모병원 임상병리학교실
임근우 ( Lim Keun-Woo )
가톨릭대학교 의과대학 의정부성모병원 외과
KMID : 0371320010600060649
Abstract
Purpose
We evaluated the correlation between clinicopathologic features and p53, c-erbB-2 and Ki-67 protein expression in gallbladder carcinoma.
Methods
From Jan. 1994 to July 1999, thirty-four cases of gallbladder carcinoma were enrolled in this study and their clinicopathologic findings were analyzed. We performed p53, c-erbB-2, and Ki-67 immunohistochemical staining on formalin fixed, paraffin
embedded histological sections with an antibody.
Results
The rate of overexpression of p53, c-erbB-2, and Ki-67 protein in gallbladder carcinoma was 47.1%, and 70.6%, 55.9%, respectively. The five year patient survival rate was significantly correlated only with tumor stage; the rate being 64.7%
(P=0.031)
with p53-negative tumors and 59.0% (P=0.023) with c-erbB-2-positive tumors.
Conclusion
Progressively increasing incidence of p53, c- erbB-2 and Ki-67 protein overexpression was observed in gallbladder carcinoma patients. Although this study found no correlation between the molecular markers and survival, further study will be
needed
to
evaluate the significance of p53, c-erbB-2 and Ki-67 proteins as prognostic factors.
키워드
담낭암; p53; c-erbB2; Ki-67; 면역조직화학적염색; Gallbladder cancer; p53; c-erbB-2; Ki-67; Immunohistochemical staining;
원문 및 링크아웃 정보
등재저널 정보