췌장암에서 맥관형성과 p53 단백 발현의 의의
Significance of Tumor Angiogenesis and p53 Protein Expression in Pancreatic Adenocarcinoma
김상순, 김민찬, 홍숙희,
소속 상세정보
김상순 ( Kim Sang-Sun )
동아대학교 의과대학 외과학교실
김민찬 ( Kim Min-Chan )
동아대학교 의과대학 외과학교실
홍숙희 ( Hong Sook-Hee )
동아대학교 의과대학 병리학교실
KMID : 0371320010610010086
Abstract
Purpose
This study was designed to examine the microvessel count and p53 protein expression level in pancreatic adenocarcinoma patients and to determine how they correlate with the clinicopathologic factors and prognosis. In addition, the relationship
between
angiogenesis and p53 protein expression in pancreatic adenocarcinoma patients was investigated.
Methods
Paraffin-embedded tumor tissues from 30 patients with pancreatic adenocarcinomas that were completely removed by a radical resection were retrieved and analyzed. The vessels were immunostained with anti-factor VIII polyclonal antibodies, and 5
areas
with the most discrete microvessels were counted under a ×200 field. The mean was calculated, which was defined as the angiogenesis score (AS). p53 protein expression was detected by the immunohistochemical stain method.
Results
The mean AS was 37.7±13.6. There were no significant differences in sex, age, tumor size, histologic grade, T ca
tegory (depth of invasion), N category (lymph node metastasis), pathologic stage and recurrence between the high and low AS group. The p53 protein expression rate was 73.3%, which did not correlate with the clinicopathologic factors and AS.
However,
recurrence was significantly related to the histologic grade and pathologic stage (p=0.040 and p=0.029). Among the various clinicopathologic factors, the N category (lymph node metastasis), the AS and recurrence (p=0.025, p=0.029 and p=0.003)
were
statistically significant according to a univariate survival analysis. In theCox regression analysis, the N category (lymph node metastasis) and recurrence were independent prognostic factors (odds ratio=4.344, 4.263).
Conclusion
Although the survival rate in the high AS group was significantly lower than that in low AS group (p=0.029), the angiogenesis assessed by the microvessel count using immunohistochemical staining was not an independent prognostic factor in the Cox
regression analysis.
키워드
췌장선암종; 종양맥관형성; p53 단백; 예후; 재발; Pancreatic adenocarcinoma; Tumor angiogenesis; p53 protein; Prognosis; Recurrence;
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