미분화 갑상선 암에 대한 임상적 고찰
Clinical Analysis of Anaplastic Thyroid Carcinoma
김현영, 정기욱, 김활웅, 윤여규, 오승근,
소속 상세정보
김현영 ( Kim Hyun-Young )
서울대학교 의과대학 외과학교실
정기욱 ( Chung Ki-Wook )
서울대학교 의과대학 외과학교실
김활웅 ( Kim Hwal-Woong )
서울대학교 의과대학 병리학교실
윤여규 ( Youn Yeo-Kyu )
서울대학교 의과대학 외과학교실
오승근 ( Oh Seung-Keun )
서울대학교 의과대학 외과학교실
KMID : 0371320010610020142
Abstract
Purpose
Anaplastic thyroid carcinoma is characterized by a rapid growing mass of the neck and an early infiltration into the surrounding tissue. Because of its mature expression in elderly patients who have a poor general physical condition, a difficulty
in
diagnosis and the lack of effective treatment, it is one of the most lethal cancers that occur in human. The aim of this study was to investigate the clinicopathologic character of anaplastic thyroid carcinoma and analyze the prognostic factors
affecting the survival rate.
Methods
The history of twenty patients who were diagnosed as having anaplastic thyroid carcinoma at Seoul National University Hospital between 1985 and 1999 were reviewed retrospectively.
Results
The most common symptom was a rapidly enlarging neck mass. Ten (55.5%) of 18 patients had concomitant well differentiated thyroid carcinomas and 5 (27.8%) patients had benign thyroid disease on the basis of the presenting pathologic features. The
median
survival time was 5.5 months and the 2-year survival rate was 27.3%. Among several factors that were analyzed, a tumor size smaller than 5 cm (p＜0.001), the absence of distant metastases at presentation (p=0.020), patients that were selected for
curative surgical resection (p=0.002), and postoperative radiotherapy (p=0.003) were associated with prolonged survival time.
Conclusion
In the selected patients (tumor size＜5 cm, the absence of distant metastases at presentation, young age (＜55)), curative surgical resection and adjuvant radiotherapy may result in an increased survival time.
키워드
미분화 갑상선 암; Anaplastic thyroid carcinoma;
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