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À§¾Ï¿¡¼­ p27Kip1 ´Ü¹éÁúÀÇ ¹ßÇö°ú ¿¹ÈÄ¿ÍÀÇ »ó°ü°ü°è Expression of p27Kip1 Protein Associated with Poor Clinical Outcome in Human Gastric Cancer

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ºÎµ¿¼ö ( Bu Dong-Su ) 
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ÇѼ¼È¯ ( Han Se-Hwan ) 
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±è±âȯ ( Kim Ki-Whan ) 
ÀÎÁ¦´ëÇб³ ÀÇ°ú´ëÇÐ »ó°è¹éº´¿ø ¿Ü°úÇб³½Ç
±èÈ«ÁÖ ( Kim Hong-Joo ) 
ÀÎÁ¦´ëÇб³ ÀÇ°ú´ëÇÐ »ó°è¹éº´¿ø ¿Ü°úÇб³½Ç
±è¿µ´ö ( Kim Young-Duck ) 
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±èÈ«¿ë ( Kim Hong-Yong ) 
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¹Ú°æ¹Ì ( Park Kyeong-Mee ) 
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Abstract


Purpose
p27Kip1 protein is an inhibitor of cyclin-dependent kinases and is thought to be a potential prognostic indicator for numerous human cancers. We investigated the expression of p27Kip1 in gastric cancer in order to estimate its clinical utility.
Methods
Immunohistochemical assay for p27Kip1 protein was performed in 64 patients with primary gastric cancer. The correlation between p27Kip1 and clinical-biological parameters including patient survival was analyzed.
Results
p27Kip1 expression was suppressed in 40 (62.5%) of 64 gasr..EABS:

Å°¿öµå

¼¼Æ÷ Áõ½Ä; ¸é¿ªÈ­Çп°»ö; ¿¹ÈÄ; À§¾Ï; p27Kip1; Cell proliferation; Immunohistochemistry; Prognosis; Gastric cancer; p27Kip1;

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