양의 태아를 이용한 횡격막탈장의 실험(제 1부)
Experimental Congenital Diaphragmatic Hernia in a Fetal Lamb Model (I)
한석주, 한애리, 박용원, 신동환, 김봉경, 양인숙, 황의호,
소속 상세정보
한석주 ( Han Seok-Joo )
연세대학교 의과대학 외과학교실
한애리 ( Han Ai-Ri )
연세대학교 의과대학 외과학교실
박용원 ( Park Yong-Won )
연세대학교 의과대학 산부인과학교실
신동환 ( Shin Dong-Hwan )
연세대학교 의과대학 병리학교실
김봉경 ( Kim Bong-Kyeong )
연세대학교 의과대학 임상의학연구센터
양인숙 ( Yang In-Sook )
연세대학교 의과대학 임상의학연구센터
황의호 ( Hwang Eui-Ho )
연세대학교 의과대학 외과학교실
KMID : 0371320010610030229
Abstract
Purpose
The purpose of this study was to construct a fetal animal model of congenital diaphragmatic hernia in a lamb under domestic environments.
Methods
Left-sided diaphragmatic hernias were created in seven fetal lambs at about 85 days’ gestation (experimental group). Three other fetal lambs did not receive any surgical procedure and served as control group. Four of these lambs (3 in the
experimental
group and 1 in the control group) were delivered after a sufficient intrauterine period. The morphological changes of lung development were compared between the two groups.
Results
Creation of diaphragmatic hernia resulted in marked hypoplasia in fetal lung development. In this experiment, the maternal mortality was 33.3%, and the fetal mortality was 60% which are relatively high as compared with previous reports.
Conclusion
From this data, the authors concluded that experimental fetal diaphragmatic hernia can be established although the technique for the measurement of gestational age, anesthesia and postoperative care should be improved to overcome domestic
inexperience
in using the lamb as an experimental animal.
키워드
태아수술; 선천성 횡격막탈장; 동물모델; Fetal surgery; Congenital diaphragmatic hernia; Animal model;
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