침윤성 유방암종에서 예후인자로서의 GLUT1 단백질의 발현
Prognosis of GLUT1 Expression in Human Breast Carcinoma
안형준, 이길연, 이상목, 고석환, 홍성화, 오수명, 김윤화,
소속 상세정보
안형준 ( Ahn Hyung-Joon )
경희대학교 의과대학 외과학교실
이길연 ( Lee Kil-Yeon )
경희대학교 의과대학 외과학교실
이상목 ( Lee Sang-Mok )
경희대학교 의과대학 외과학교실
고석환 ( Koh Suck-Hwan )
경희대학교 의과대학 외과학교실
홍성화 ( Hong Sung-Wha )
경희대학교 의과대학 외과학교실
오수명 ( Oh Soo-Myung )
경희대학교 의과대학 외과학교실
김윤화 ( Kim Youn-Hwa )
경희대학교 의과대학 해부병리학교실
KMID : 0371320010610030247
Abstract
Purpose: An increase of glucose uptake and glycolytic metabolism has been reported in malignant cells as compared with normal cells and tissues. We hypothesized that human erythrocyte glucose transporter-1 (GLUT1) expression is increased in breastcarcinoma andmay be correlated with long term clinical outcome.
Methods: Two hundred ninety formalin fixed, paraffin embedded sections of infiltrating ductal carcinomas of the breast were immunostained with anti-GLUT1.
Results: Among the known clinicopathological prognostic factors, GLUT1 expression was correlated positively with histological grade (p=0.000) and tumor size (p=0.003). In a multivariate analysis, lymph node i
nvolvement and GLUT1 expression were statistically significant prognostic factors. The cummulative survival rates of GLUT1 expression and LN involvement were statistically significant (p=0.0061, p=0.0009) respectively. Our results suggest that 1) GLUT1 expression is correlated with histological grade and tumor size, and 2) GLUT1 expression correlates with a poorer prognosis in patients with infiltrating ductal carcinoma of the breast.
Conclusion: The results of our study suggest that immunohistochemical staining of GLUT1 expression is strongly associated with neoplastic progression in breast carcinoma, and that GLUT1 expression has value in estimating the prognosis of patients with breast carcinoma.
키워드
유방암; GLUT1 발현; 예후; Breast cancer; GLUT1 expression; Prognosis;
원문 및 링크아웃 정보
등재저널 정보