위장관 간질종양의 임상병리학적 소견과 예후인자들에 대한 연구
Gastrointestinal Stromal Tumors; Clinicopathological Features and Prognostic Factors
하도원, 박찬흔,
소속 상세정보
하도원 ( Ha Do-Won )
한림대학교 의과대학 외과학교실
박찬흔 ( Park Chan-Heum )
한림대학교 의과대학 외과학교실
KMID : 0371320010610030295
Abstract
Purpose
Gastrointestinal stromal tumors (GIST) are a heterogenous group of mesenchymal neoplasms of the gastrointestinal tract. This study was performed to determine the clinical characteristics and prognostic factors of GIST.
Methods
We studied 24 cases of GIST collected over a 9 year period. This retrospective review analyzed the clinical presentation, pathologic examination, and long-term follow-up of patients with GIST. The clinicopathological features were evaluated to
identify
the predictors of survival.
Results
The most common clinical presentation was pain or discomfort (37.5%). GISTs were found to be typically present in old
er individuals and be most common in the stomach (41.7%). All patients underwent surgical resection with curative intent. The follow-up period ranged from 3 to 110 months. Recurrence occurred in 11 (45.8%) of 24 patients. According to
multivariate
analysis, survival was inversely correlated with size (P=0.032) and the number of mitoses (P=0.030). Patients younger than 50 had an independent value for prognostic prediction (P=0.058).
Conclusion
Tumor size, mitotic index and patient’s age can be used as prognostic factors for GIST according to the results of our study. But, better pathological and immunohistochemical methods are still required to improve GIST prognosis.
키워드
위장관 간질종양; 임상양상; 예후인자; GIST (gastrointestinal stromal tumor); Clinical characteristics; Prognostic factor;
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